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AuthorEl-Tahry, H.
AuthorMarei, Hany E.
AuthorShams, A.
AuthorEl-Shahat, M.
AuthorAbdelaziz, H.
AuthorAbd El-kader, M.
Available date2016-09-28T07:29:59Z
Publication Date2016-06
Publication NameTissue and Cell
Identifierhttp://dx.doi.org/10.1016/j.tice.2016.03.001
CitationH. El-Tahry, Hany E. Marei, A. Shams, M. El-Shahat, H. Abdelaziz, M. Abd El-kader, "The effect of triiodothyronine on maturation and differentiation of oligodendrocyte progenitor cells during remyelination following induced demyelination in male albino rat," Tissue and Cell, Volume 48, Issue 3, June 2016, Pages 242-251,
ISSN00408166
URIhttp://www.sciencedirect.com/science/article/pii/S0040816615300495
URIhttp://hdl.handle.net/10576/4789
AbstractDemyelination was induced by two weeks cuprizone treatment. Rats of +ve control and triiodothyronine (T3) then received three subcutaneous injections of either saline or T3 day after day and sacrificed at the end of the third and fifth weeks. Animals in −ve control group received only standard rodent chow. After one week of cuprizone withdrawal the corpus callosum in +ve control and T3 treated rats was still demyelinated as revealed by MBP immunohistochemistry. The assay of PLP gene showed significant increase of T3 treated group compared to both the −ve control and +ve control groups. After three weeks, significant improvement in myelination was detected in T3-treated group compared to +ve control as detected by both MBP immunohistochemistry and electron microscopy. After one week of cuprizone withdrawal, PDGFRα positive cells and gene expression showed significant increase in +ve control and T3-treated groups as compared to −ve control with insignificant difference in between the former two groups. After three weeks of cuprizone withdrawal, PDGFRα positive cells in T3-treated and +ve control groups decreased to the control levels. These results suggest that T3 was effective in improving remyelination when administered during acute phase and might direct progenitor lineage toward oligodendrocytes.
Languageen
PublisherElsevier, Ltd
SubjectTriiodothyronine
Cuprizone
Remyelination
Oligodendrocyte progenitor cells
TitleThe effect of triiodothyronine on maturation and differentiation of oligodendrocyte progenitor cells during remyelination following induced demyelination in male albino rat
TypeArticle
Issue Number3
Volume Number48
dc.accessType Open Access


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