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المؤلفIsmail, Helene
المؤلفShakkour, Zaynab
المؤلفTabet, Maha
المؤلفAbdelhady, Samar
المؤلفKobaisi, Abir
المؤلفAbedi, Reem
المؤلفNasrallah, Leila
المؤلفPintus, Gianfranco
المؤلفAl-Dhaheri, Yusra
المؤلفMondello, Stefania
المؤلفEl-Khoury, Riyad
المؤلفEid, Ali H.
المؤلفKobeissy, Firas
المؤلفSalameh, Johnny
تاريخ الإتاحة2023-09-25T10:26:16Z
تاريخ النشر2020
اسم المنشورAntioxidants
المصدرScopus
معرّف المصادر الموحدhttp://dx.doi.org/10.3390/antiox9100943
معرّف المصادر الموحدhttp://hdl.handle.net/10576/47942
الملخصTraumatic brain injury (TBI) is a major health concern worldwide and is classified based on severity into mild, moderate, and severe. The mechanical injury in TBI leads to a metabolic and ionic imbalance, which eventually leads to excessive production of reactive oxygen species (ROS) and a state of oxidative stress. To date, no drug has been approved by the food and drug administration (FDA) for the treatment of TBI. Nevertheless, it is thought that targeting the pathology mechanisms would alleviate the consequences of TBI. For that purpose, antioxidants have been considered as treatment options in TBI and were shown to have a neuroprotective effect. In this review, we will discuss oxidative stress in TBI, the history of antioxidant utilization in the treatment of TBI, and we will focus on two novel antioxidants, mitoquinone (MitoQ) and edaravone. MitoQ can cross the blood brain barrier and cellular membranes to accumulate in the mitochondria and is thought to activate the Nrf2/ARE pathway leading to an increase in the expression of antioxidant enzymes. Edaravone is a free radical scavenger that leads to the mitigation of damage resulting from oxidative stress with a possible association to the activation of the Nrf2/ARE pathway as well.
راعي المشروعFunding: This research was funded by UAEU Program for Advanced Research, grant number 31S398-UPAR to Yusra Al Dhaheri.
اللغةen
الناشرMDPI
الموضوعAnti-oxidants
Edaravone
Mitoquinone
Oxidative stress
Traumatic brain injury
العنوانTraumatic brain injury: Oxidative stress and novel anti-oxidants such as mitoquinone and edaravone
النوعArticle Review
الصفحات1-18
رقم العدد10
رقم المجلد9
dc.accessType Open Access


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