Show simple item record

AuthorIsmail, Helene
AuthorShakkour, Zaynab
AuthorTabet, Maha
AuthorAbdelhady, Samar
AuthorKobaisi, Abir
AuthorAbedi, Reem
AuthorNasrallah, Leila
AuthorPintus, Gianfranco
AuthorAl-Dhaheri, Yusra
AuthorMondello, Stefania
AuthorEl-Khoury, Riyad
AuthorEid, Ali H.
AuthorKobeissy, Firas
AuthorSalameh, Johnny
Available date2023-09-25T10:26:16Z
Publication Date2020
Publication NameAntioxidants
ResourceScopus
URIhttp://dx.doi.org/10.3390/antiox9100943
URIhttp://hdl.handle.net/10576/47942
AbstractTraumatic brain injury (TBI) is a major health concern worldwide and is classified based on severity into mild, moderate, and severe. The mechanical injury in TBI leads to a metabolic and ionic imbalance, which eventually leads to excessive production of reactive oxygen species (ROS) and a state of oxidative stress. To date, no drug has been approved by the food and drug administration (FDA) for the treatment of TBI. Nevertheless, it is thought that targeting the pathology mechanisms would alleviate the consequences of TBI. For that purpose, antioxidants have been considered as treatment options in TBI and were shown to have a neuroprotective effect. In this review, we will discuss oxidative stress in TBI, the history of antioxidant utilization in the treatment of TBI, and we will focus on two novel antioxidants, mitoquinone (MitoQ) and edaravone. MitoQ can cross the blood brain barrier and cellular membranes to accumulate in the mitochondria and is thought to activate the Nrf2/ARE pathway leading to an increase in the expression of antioxidant enzymes. Edaravone is a free radical scavenger that leads to the mitigation of damage resulting from oxidative stress with a possible association to the activation of the Nrf2/ARE pathway as well.
SponsorFunding: This research was funded by UAEU Program for Advanced Research, grant number 31S398-UPAR to Yusra Al Dhaheri.
Languageen
PublisherMDPI
SubjectAnti-oxidants
Edaravone
Mitoquinone
Oxidative stress
Traumatic brain injury
TitleTraumatic brain injury: Oxidative stress and novel anti-oxidants such as mitoquinone and edaravone
TypeArticle Review
Pagination1-18
Issue Number10
Volume Number9
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record