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السجلات المعروضة 1 -- 10 من 10

    • A population study of clinically actionable genetic variation affecting drug response from the Middle East 

      Jithesh, Puthen Veettil; Abuhaliqa, Mohammed; Syed, Najeeb; Ahmed, Ikhlak; El Anbari, Mohammed; ... more authors ( Nature Research , 2022 , Article)
      Clinical implementation of pharmacogenomics will help in personalizing drug prescriptions and alleviate the personal and financial burden due to inefficacy and adverse reactions to drugs. However, such implementation is ...

    • Analytic comparison between three high-throughput commercial SARS-CoV-2 antibody assays reveals minor discrepancies in a high-incidence population 

      Nasrallah, Gheyath K; Dargham, Soha R; Shurrab, Farah; Al-Sadeq, Duaa W; Al-Jighefee, Hadeel; ... more authors ( Nature Research , 2021 , Article)
      Performance of three automated commercial serological IgG-based assays was investigated for assessing SARS-CoV-2 "ever" (past or current) infection in a population-based sample in a high exposure setting. PCR and serological ...

    • Duration of mRNA vaccine protection against SARS-CoV-2 Omicron BA.1 and BA.2 subvariants in Qatar. 

      Chemaitelly, Hiam; Ayoub, Houssein H; AlMukdad, Sawsan; Coyle, Peter; Tang, Patrick; ... more authors ( Nature Research , 2022 , Article)
      SARS-CoV-2 Omicron BA.1 and BA.2 subvariants are genetically divergent. We conducted a matched, test-negative, case-control study to estimate duration of protection of the second and third/booster doses of mRNA COVID-19 ...

    • Evaluation of commercially available fully automated and ELISA-based assays for detecting anti-SARS-CoV-2 neutralizing antibodies 

      Zedan, Hadeel T.; Yassine, Hadi M.; Al-Sadeq, Duaa W.; Liu, Na; Qotba, Hamda; ... more authors ( Nature Research , 2022 , Article)
      Rapid and accurate measurement of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)-specific neutralizing antibodies (nAbs) is paramount for monitoring immunity in infected and vaccinated subjects. The current ...

    • Insights into the Middle Eastern paternal genetic pool in Tunisia: high prevalence of T-M70 haplogroup in an Arab population 

      Elkamel, Sarra; Marques, Sofia L.; Alvarez, Luis; Gomes, Veronica; Boussetta, Sami; ... more authors ( Nature Research , 2021 , Article)
      To obtain refreshed insights into the paternal lineages of Tunisian populations, Y-chromosome diversity was assessed in two populations belonging to an Arab genealogical lineage, Kairouan and Wesletia, as well as in four ...

    • Preparation, characterization and therapeutic properties of gum arabic-stabilized gallic acid nanoparticles. 

      Hassani, Abdelkader; Azarian, Mohammad Mahdi Sabaghpour; Ibrahim, Wisam Nabeel; Hussain, Siti Aslina ( Nature Research , 2020 , Article)
      Gallic acid (GA) is a natural phenolic compound with therapeutic effects that are often challenged by its rapid metabolism and clearance. Therefore,  GA was encapsulated using gum arabic into nanoparticles to increase its ...

    • Prevalence, predictors, and outcomes of major congenital anomalies: A population-based register study 

      Al-Dewik, Nader; Samara, Muthanna; Younes, Salma; Al-jurf, Rana; Nasrallah, Gheyath; ... more authors ( Nature Research , 2023 , Article)
      Congenital anomalies (CAs) are a leading cause of morbidity and mortality in early life. We aimed to assess the incidence, risk factors, and outcomes of major CAs in the State of Qatar. A population-based retrospective ...

    • Protection of Omicron sub-lineage infection against reinfection with another Omicron sub-lineage 

      Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; Yassine, Hadi M.; ... more authors ( Nature Research , 2022 , Article)
      There is significant genetic distance between SARS-CoV-2 Omicron (B.1.1.529) variant BA.1 and BA.2 sub-lineages. This study investigates immune protection of infection with one sub-lineage against reinfection with the other ...

    • The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals 

      Singh, Parul; Rawat, Arun; Alwakeel, Mariam; Sharif, Elham; Al Khodor, Souhaila ( Nature Research , 2020 , Article)
      Vitamin D deficiency affects approximately 80% of individuals in some countries and has been linked with gut dysbiosis and inflammation. While the benefits of vitamin D supplementation on the gut microbiota have been studied ...

    • Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes 

      Razali, Rozaimi Mohamad; Rodriguez-Flores, Juan; Ghorbani, Mohammadmersad; Naeem, Haroon; Aamer, Waleed; ... more authors ( Nature Research , 2021 , Article)
      Arab populations are largely understudied, notably their genetic structure and history. Here we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive diversity as well as genetic ancestries ...