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Investigation of the genetic structure of Kabyle and Chaouia Algerian populations through the polymorphism of Alu insertion markers
(
Taylor and Francis Ltd
, 2019 , Article)
Background: In Algeria, as in all North Africa, Berbers constitute the old background of the population. Today, Berber speakers account for only ∼ 25% of Algerians. This decline is the product of a complex human settlement ...
Cadmium induces migration of colon cancer cells: Roles of reactive oxygen species, p38 and cyclooxygenase-2
(
Cell Physiol Biochem Press GmbH & Co KG
, 2019 , Article)
Background/Aims: Cadmium (Cd) is a heavy metal contaminant whose toxicity is associated with colorectal cancer (CRC). However, the underlying molecular mechanisms of Cd-induced CRC malignancy remain obscure. Methods: A ...
Prevalence of general and abdominal obesity among adolescents attending independent schools in Qatar
(
Emerald Group Publishing Ltd.
, 2019 , Article)
Purpose: The purpose of this paper is to determine the prevalence of general and abdominal obesity among adolescents attending independent schools in Qatar. Design/methodology/approaches: A school-based cross-sectional ...
A computational method to characterize the missense mutations in the catalytic domain of GAA protein causing Pompe disease.
(
Wiley
, 2019 , Article)
Pompe disease is an autosomal recessive lysosomal storage disease caused by acid α-glucosidase (GAA) deficiency, resulting in intralysosomal accumulation of glycogen, including cardiac, skeletal, and smooth muscle cells. ...
Amelioration of perivascular adipose inflammation reverses vascular dysfunction in a model of nonobese prediabetic metabolic challenge: potential role of antidiabetic drugs
(
Mosby Inc.
, 2019 , Article)
The onset of vascular impairment precedes that of diagnostic hyperglycemia in diabetic patients suggesting a vascular insult early in the course of metabolic dysfunction without a well-defined mechanism. Mounting evidence ...
Frizzled 4 regulates ventral blood vessel remodeling in the zebrafish retina
(
Wiley
, 2019 , Article)
Familial exudative vitreoretinopathy (FEVR) is a rare congenital disorder characterized by a lack of blood vessel growth to the periphery of the retina with secondary fibrovascular proliferation at the vascular-avascular ...
Biocompatibility and toxicity of novel iron chelator Starch-Deferoxamine (S-DFO) compared to zinc oxide nanoparticles to zebrafish embryo: An oxidative stress based apoptosis, physicochemical and neurological study profile.
(
Elsevier
, 2019 , Article)
Clinically approved iron chelators are effective in decreasing significant transfusional iron accumulation. Starch-Deferoxamine (S-DFO), a novel high molecular weight iron chelator, was produced to increase binding capacity ...
Conception, Implementation, and Integration of Heterogenous Information Technology Infrastructures in the Qatar Biobank
(
Mary Ann Liebert
, 2019 , Article)
The overall goal of the Qatar Biobank (QBB) is to collect, manage, and distribute high-quality human biospecimens with appropriate clinical and/or research annotation and associated phenotypic data, aiming to be an important ...
miR-20b, miR-296, and Let-7f Expression in Human Adipose Tissue is Related to Obesity and Type 2 Diabetes.
(
Wiley
, 2019 , Article)
This study aimed to analyze the potential association of different microRNA (miRNA) molecules with both type 2 diabetes (T2D) and obesity and determine their target genes. Quantitative PCR was used to analyze the miR-20b, ...
Identification of potential inhibitors against pathogenic missense mutations of PMM2 using a structure-based virtual screening approach.
(
Taylor & Francis
, 2019 , Article)
The autosomal recessive phosphomannomutase 2-congenital disorder of glycosylation (PMM2-CDG) is characterized by defective functioning of the PMM2 enzyme, which is necessary for the conversion of mannose-6-phosphate into ...