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Computational insights of K1444N substitution in GAP-related domain of NF1 gene associated with neurofibromatosis type 1 disease: a molecular modeling and dynamics approach
(
Springer New York LLC
, 2018 , Article)
The NF1 gene encodes for neurofibromin protein, which is ubiquitously expressed, but most highly in the central nervous system. Non-synonymous SNPs (nsSNPs) in the NF1 gene were found to be associated with Neurofibromatosis ...
Prevalence of nephropathy in type 1 diabetes in the Arab world: A systematic review and meta-analysis
(
John Wiley and Sons Ltd
, 2018 , Article Review)
The aim of this study was to conduct a systematic review and meta-analysis and determine the prevalence of diabetic nephropathy (DN) among Arab patients with T1D. A systematic literature search was conducted using 4 different ...
Meta-analysis of the incidence of lead dislodgement with conventional and leadless pacemaker systems
(
Blackwell Publishing Inc.
, 2018 , Article Review)
Introduction
Leadless cardiac pacemaker (LCP) implantation using a transcatheter was recently developed to avoid pocket- and lead-related complications. Although a LCP has an active fixation mechanism using tines or a ...
A potential link between oxidative stress and endothelial-to-mesenchymal transition in systemic sclerosis
(
Frontiers Media S.A.
, 2018 , Article Review)
Systemic sclerosis (SSc), an autoimmune disease that is associated with a number of genetic and environmental risk factors, is characterized by progressive fibrosis and microvasculature damage in the skin, lungs, heart, ...
Design and synthesis of novel thioethers derived from 1,5-diphenyl-6-thioxo-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones as antiangiogenic agents
(
Bentham
, 2018 , Article)
Background: In attempts to discover new antiangiogenic entities, a novel series of thioethers derived from 6-thioxo-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidine-4(5H)ones was considered and designed. Methods: Virtual screening ...