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Genetic epidemiology of ovarian cancer in the 22 Arab countries: A systematic review.
(
Elsevier
, 2019 , Article)
Ovarian cancer (OC) is a common disease among Arabs, with one of the highest incidences in the world. OC is underdiagnosed, underreported, and mostly reported with breast cancer. This study aimed to conduct a systematic ...
Quantitative metabolomic and lipidomic profiling reveals aberrant amino acid metabolism in type 2 diabetes
(
Royal Society of Chemistry
, 2013 , Article)
Type 2 diabetes (T2DM) is a multi-factorial disease with a complex pathogenic mechanism; however a complete understanding of precise biochemical alterations accompanying the onset and progression of T2DM is lacking. Using ...
Canavan disease: an Arab scenario.
(
Elsevier Inc.
, 2015 , Article)
The autosomal recessive Canavan disease (CD) is a neurological disorder that begins in infancy. CD is caused by mutations in the gene encoding the ASPA enzyme. It has been reported with high frequency in patients with ...
Analysis of the Qatari R336C Cystathionine β-Synthase Protein in Mice.
(
Wiley
, 2019 , Article)
Classical homocystinuria is a recessive inborn error of metabolism caused by mutations in the cystathionine beta-synthase (CBS) gene. The highest incidence of CBS deficiency in the world is found in the country of Qatar ...
The cardiovascular implication of single nucleotide polymorphisms of chromosome 9p21 locus among Arab population
(
Wolters Kluwer Health
, 2015 , Article)
Background: Based on several reports including genome-wide association studies, genetic variability has been linked with higher (nearly half) susceptibility toward coronary artery disease (CAD). We aimed to evaluate the ...
Antitumor Activities of the Novel Isosteviol Derivative 10C Against Liver Cancer
(
International Institute of Anticancer Research
, 2017 , Article)
Background/Aim. Hepatocellular carcinoma (HCC) is the most common type of liver cancer and the fifth most common primary malignancy with worldwide increasing incidence. The current study aims to investigate the anticancer ...
The prevalence of vitamin d deficiency among female college students at Qatar University
(
Saudi Arabian Armed Forces Hospital
, 2011 , Article)
N/A.
A comprehensive review on the anti-cancer properties and mechanisms of action of sesamin, a lignan in sesame seeds (Sesamum indicum).
(
Elsevier
, 2017 , Article)
Sesamin is the major active ingredient is Sesamum indicum seeds. Several studies revealed that sesamin possesses potent anti-cancer properties. The anti-cancer effects of sesamin have been mainly attributed to its ...
Design and synthesis of novel thioethers derived from 1,5-diphenyl-6-thioxo-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones as antiangiogenic agents
(
Bentham
, 2018 , Article)
Background: In attempts to discover new antiangiogenic entities, a novel series of thioethers derived from 6-thioxo-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidine-4(5H)ones was considered and designed. Methods: Virtual screening ...
A computational model to predict the structural and functional consequences of missense mutations in O6-methylguanine DNA methyltransferase
(
Elsevier
, 2019 , Article)
DNA repair mechanism is a process through which the cell repairs its damaged DNA. Although there are several mechanisms involved in the DNA repair mechanisms, the direct reversal method is the simplest and does not require ...