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Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa
(
Taylor & Francis
, 2017 , Article)
Over the past two decades, studies have documented the wide-range anti-cancer effects of Nigella sativa, known as black seed or black cumin. Thymoquinone (TQ), its major active ingredient, has also been extensively studied ...
Comparative Phylogenetic and Residue Analysis of Hepatitis C Virus E1 Protein from the Middle East and North Africa Region
(
Kowsar (Research Center for Gastroenterology and Liver Diseases, Tehran, Iran)
, 2019 , Article)
Hepatitis C virus (HCV) is a major public health problem in the Middle East and North Africa (MENA) region with an estimate of over 15 million chronically infected patients. However, molecular characterization of circulating ...
Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach
(
Plos One
, 2017 , Article)
Maturity-onset diabetes of the young type 3 (MODY3) is a non-ketotic form of diabetes associated with poor insulin secretion. Over the past years, several studies have reported the association of missense mutations in the ...
Antihypertensive indigenous lebanese plants: Ethnopharmacology and a clinical trial
(
MDPI AG
, 2019 , Article)
Hypertension is highly prevalent among the Lebanese adult population and is indeed the major cause of mortality in Lebanon. Traditional use of antihypertensive medicinal plants has long been practiced. The aim of this study ...
Associations of Vitamin D Receptor Polymorphism rs1544410 with Adiposity Phenotypes
(
MedCrave
, 2016 , Article)
Background: Vitamin D receptor (VDR) is present on adipocytes, and many studies were performed to investigate the association between polymorphisms in VDR gene with obesity. However, in the Arab Gulf populations, whereas ...
Prevalence of anelloviruses (TTV, TTMDV, and TTMV) in healthy blood donors and in patients infected with HBV or HCV in Qatar
(
BioMed Central
, 2016 , Article)
Background
Anelloviruses (TTV, TTMV, and TTMDV) have been associated with non A-G hepatitis. The goal of the current study was to estimate the prevalence of these anelloviruses in Qatar.
Methods
A total of 607 blood ...
Genetic Epidemiology of Glucose-6-Dehydrogenase Deficiency in the Arab World
(
Nature Publishing Group
, 2016 , Article)
A systematic search was implemented using four literature databases (PubMed, Embase, Science Direct and Web of Science) to capture all the causative mutations of Glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDD) ...
Synthesis, characterization, and antimicrobial properties of novel double layer nanocomposite electrospun fibers for wound dressing applications
(
Dove Press
, 2017 , Article)
Herein, novel hybrid nanomaterials were developed for wound dressing applications with antimicrobial properties. Electrospinning was used to fabricate a double layer nanocomposite nanofibrous mat consisting of an upper ...
7-O-methylpunctatin, a novel homoisoflavonoid, inhibits phenotypic switch of human arteriolar smooth muscle cells
(
MDPI AG
, 2019 , Article)
Remodeling of arterioles is a pivotal event in the manifestation of many inflammation-based cardio-vasculopathologies, such as hypertension. During these remodeling events, vascular smooth muscle cells (VSMCs) switch from ...
PopPAnTe: population and pedigree association testing for quantitative data.
(
BioMed Central
, 2017 , Article)
Family-based designs, from twin studies to isolated populations with their complex genealogical data, are a valuable resource for genetic studies of heritable molecular biomarkers. Existing software for family-based studies ...