Biomedical Sciences: Recent submissions
Now showing items 741-760 of 832
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Computational screening of known broad-spectrum antiviral small organic molecules for potential influenza HA stem inhibitors.
( Public Library of Science , 2018 , Article)With the emergence of new influenza virus strains that are resistant to current inhibitors such as oseltamivir (anti-neuraminidase (NA)) and amantadine (anti-M2 proton channel), influenza A viruses continue to be a serious ... -
Inositol 1,4,5-Trisphosphate Receptors in Hypertension.
( Frontiers Media , 2018 , Article Review)Chronic hypertension remains a major cause of global mortality and morbidity. It is a complex disease that is the clinical manifestation of multiple genetic, environmental, nutritional, hormonal, and aging-related disorders. ... -
The march of pluripotent stem cells in cardiovascular regenerative medicine.
( BMC , 2018 , Article Review)Cardiovascular disease (CVD) continues to be the leading cause of global morbidity and mortality. Heart failure remains a major contributor to this mortality. Despite major therapeutic advances over the past decades, a ... -
Performance evaluation of five commercial assays in assessing seroprevalence of HEV antibodies among blood donors
( Microbiology Society , 2018 , Article)Although hepatitis E virus (HEV) is mainly transmitted via the faecal-oral route, the rate of HEV transmission via blood donation is on the rise. However, the seroprevalence of HEV among blood donors is not well established ... -
Adipose tissue dysfunction in cancer cachexia
( Wiley Periodicals, Inc. , 2018 , Article)Cancer cachexia is a complex disorder that is driven by inflammation and metabolic imbalances, resulting in extreme weight loss. Adipose tissue, a main player in cancer cachexia, is an essential metabolic and secretory ... -
Protective Effect of Cyclically Pressurized Solid⁻Liquid Extraction Polyphenols from Grape Pomace on Oxidative Endothelial Cell Death.
( MDPI , 2018 , Article)The aim of this work is the evaluation of a green extraction technology to exploit winery waste byproducts. Specifically, a solid⁻liquid extraction technology (Naviglio Extractor) was used to obtain polyphenolic antioxidants ... -
Toxicity evaluation of selected ionic liquid compounds on embryonic development of Zebrafish.
( Elsevier , 2018 , Article)Hydrate formation in seafloor pipelines is considered an economic and flow assurance issue for the oil and gas industries. Ionic liquids (ILs) have been recently used as potential hydrate inhibitors. Although branded as ... -
Breast cancer in the GCC countries: A focus on BRCA1/2 and non-BRCA1/2 genes.
( Elsevier , 2018 , Article)The GCC is an economic alliance of six Arab countries, including Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and United Arab Emirates (UAE). The rate of endogamous marriage among the GCC countries is approaching 100%, with ... -
Epstein–Barr Virus Epidemiology, Serology, and Genetic Variability of LMP-1 Oncogene Among Healthy Population: An Update
( Frontiers Medi , 2018 , Article Review)The Epstein–Barr virus (EBV) is a DNA lymphotropic herpesvirus and the causative agent of infectious mononucleosis. EBV is highly prevalent since it affects more than 90% of individuals worldwide and has been linked to ... -
Reduced vasorin enhances angiotensin II signaling within the aging arterial wall
( Impact Journals , 2018 , Article)The glycosylated protein vasorin physically interacts with the transforming growth factor-beta1 (TGF-β1) and functionally attenuates its fibrogenic signaling in the vascular smooth muscle cells (VSMCs) of the arterial wall. ... -
Ecotoxicological assessment of Ti3C2Tx (MXene) using a zebrafish embryo model
( Royal Society of Chemistry , 2018 , Article)The recent application of 2D Ti3C2Tx (MXene) nanomaterials as adsorbents and membranes for water treatment as well as for biomedical applications is attracting a growing interest. However, the environmental impact of MXene ... -
Performance evaluation of four type-specific commercial assays for detection of herpes simplex virus type 1 antibodies in a Middle East and North Africa population.
( Elsevier , 2018 , Article)The number of diagnostic assays for the detection of herpes simplex virus type 1 (HSV-1) antibodies has increased over the years. However, their performance characteristics could vary among global populations. To investigate ... -
Laboratory challenges in the diagnosis of hepatitis E virus.
( Microbiology Society , 2018 , Article Review)Hepatitis E virus (HEV) is an RNA virus that is an important cause of both acute and chronic hepatitis worldwide. To date, there are eight HEV genotypes that can infect mammals. HEV-1 and HEV-2 infect exclusively humans, ... -
Herpes Simplex Virus Type 2 Seroprevalence Among Different National Populations of Middle East and North African Men
( Lippincott, Williams & Wilkins , 2018 , Article)BACKGROUND: There are limited data on herpes simplex virus type 2 (HSV-2) seroprevalence in the Middle East and North Africa (MENA). We examined country- and age-specific HSV-2 seroprevalence among select MENA populations ... -
A systematic investigation of the bio-toxicity of core-shell magnetic mesoporous silica microspheres using zebrafish model
( Elsevier , 2018 , Article)Abstract In this work, shearing interface coassembly in biliquid phase systems is employed to synthesize biocompatible core-shell magnetic mesoporous silica microspheres with uniform size of about 600 nm, perpendicular ... -
The effects of oxygen concentration on in vitro output of prostaglandin E2 and interleukin-6 from human fetal membranes.
( Oxford University Press , 2007 , Article)Labour at all gestational ages has clear biochemical parallels with an inflammatory response, typified by the increased output of prostaglandins (PGs) and cytokines within the pregnant uterus. The main sources are the fetal ... -
First study in Qatar to reveal high Legionella counts in cooling towers.
( World Health Organization (WHO) , 2017 , Article)Legionella spp. is transmitted from water to humans by aerosol-generating devices, including cooling towers (CTs). There have not been published reports about Legionella in these systems in Qatar. Ten CTs in Qatar University ... -
Prevalence and molecular profiling of Epstein Barr virus (EBV) among healthy blood donors from different nationalities in Qatar.
( Public Library of Science , 2017 , Article)The Epstein-Barr virus (EBV) is the causative agent of infectious mononucleosis. EBV is highly prevalent lymphotropic herpesvirus and has been linked to several malignancies. Transmission is generally by oral secretions, ... -
Zebrafish larvae as a model to demonstrate secondary iron overload.
( Wiley , 2018 , Article)Thalassemia is the most common genetically inherited blood disorder arising from a defect in hemoglobin production, resulting in ineffective erythropoiesis and severe hemolytic anemia. While transfusion therapy corrects ... -
Propionic acidemia in the Arab World.
( Elsevier , 2015 , Article)The autosomal recessive disease propionic acidemia (PA) is an inborn error of metabolism with highly variable clinical manifestations, caused by a deficiency of propionyl-CoA carboxylase (PCC) enzyme, due to mutations in ...
