Background Paracetamol and ibuprofen are the most commonly used medications for fever and pain management in children. While the efficacy appears similar with both drugs, there are contradictory findings related to adverse ...

Angiotensin receptor blockers (ARBs) are commonly used as a treatment for many cardiovascular diseases, but their safety has been called into question. The VALUE trial found an increased risk of myocardial infarction in ...

ObjectivesCytokine release syndrome with elevated interleukin-6 (IL-6) levels is associated with multiorgan damage and death in severe coronavirus disease 2019 (COVID-19). Our objective was to perform a living systematic ...

ObjectivesCytokine release syndrome with elevated interleukin-6 (IL-6) levels is associated with multiorgan damage and death in severe coronavirus disease 2019 (COVID-19). Our objective was to update the data in a living ...

BackgroundThe burden of Japanese encephalitis (JE) is substantial and is arguably one of the most serious viral encephalitic diseases with high case fatality and no specific treatment. JE vaccines are the only available ...

Background: Necrotizing Enterocolitis (NEC) is a major cause of morbidity and mortality in the Neonatal Intensive Care Unit (NICU), yet the global incidence of NEC has not been systematically evaluated. We conducted a ...

BackgroundTo systematically review the literature about the association between systemic corticosteroid therapy (CST) and outcomes of COVID-19 patients. MethodsWe searched Medline, Embase, EBM Reviews, Scopus, Web of ...

To investigate the effect of number of studies in a meta-analysis on the detection of publication bias using p-value driven methods. The proportion of meta-analyses detected by Egger's, Harbord's, Peters', and Begg's tests ...

Pressure injuries are localised areas of injury to the skin and/or underlying tissues. To assess foam dressings compared to other dressings in healing pressure injuries. Systematic review and meta-analysis DATA SOURCES: ...

ObjectivesIn safety assessment, studies with no events are a frequent occurrence when conducting meta-analyses. The current approach in meta-analysis is to exclude double-zero studies from the synthesis. In this study, we ...