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Platforms Exploited for SARS-CoV-2 Vaccine Development.

Mathew, Shilu; Faheem, Muhammed; Hassain, Neeraja A; Benslimane, Fatiha M; Thani, Asmaa A Al; ... more authors ... less authors ( MDPI , 2020 , Article Review)

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the only zoonotic-origin coronavirus (CoV) that has reached the pandemic stage. The virus uses its spike (S) glycoprotein to attach to the host cells ...

Prior Statins Use and Risk of Mortality and Severe Disease from COVID-19: A Systematic Review and Meta-Analysis

Yetmar, Zachary A; Chesdachai, Supavit; Kashour, Tarek; Riaz, Muhammad; Gerberi, Danielle J; ... more authors ... less authors ( Oxford University Press , 2021 , Article)

Background Statins up-regulate angiotensin converting enzyme-2, the receptor of SARS-CoV-2, while also exhibiting pleiotropic antiviral, antithrombotic and anti-inflammatory properties. Uncertainties exist about their ...

BNT162b2 antigen dose and SARS-CoV-2 omicron infection in adolescents

Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; Yassine, Hadi M.; ... more authors ... less authors ( Elsevier , 2023 , Other)

COVID-19 vaccine antigen dose might affect protection against SARS-CoV-2 infection,1, 2 but direct evidence to quantify this effect is absent. We conducted a matched, retrospective, cohort study using a regression ...

Estimates of global SARS-CoV-2 infection exposure, infection morbidity, and infection mortality rates in 2020

Houssein H., Ayoub; Mumtaz, Ghina R.; Seedat, Shaheen; Makhoul, Monia; Chemaitelly, Hiam; ... more authors ... less authors ( Elsevier , 2021 , Article)

We aimed to estimate, albeit crudely and provisionally, national, regional, and global proportions of respective populations that have been infected with SARS-CoV-2 in the first year after the introduction of this virus ...

Effectiveness of the neutralizing antibody sotrovimab among high-risk patients with mild-to-moderate SARS-CoV-2 in Qatar

Ahmed, Zaqout; Almaslamani, Muna A.; Chemaitelly, Hiam; Hashim, Samar A.; Ittaman, Ajithkumar; ... more authors ... less authors ( Elsevier , 2022 , Article)

ObjectivesTo estimate the real-world effectiveness of sotrovimab against severe, critical, or fatal COVID-19 in Qatar at a time in which most SARS-CoV-2 incidences occurred due to the BA.2 Omicron subvariant. MethodsWe ...

Association of Prior SARS-CoV-2 Infection With Risk of Breakthrough Infection Following mRNA Vaccination in Qatar.

Abu-Raddad, Laith J; Chemaitelly, Hiam; Ayoub, Houssein H; Yassine, Hadi M; Benslimane, Fatiha M; ... more authors ... less authors ( American Medical Association , 2021 , Article)

The effect of prior SARS-CoV-2 infection on vaccine protection remains poorly understood. To assess protection from SARS-CoV-2 breakthrough infection after mRNA vaccination among persons with vs without prior SARS-CoV-2 ...

Characterizing the effective reproduction number during the COVID-19 pandemic: Insights from Qatar’s experience

Bsat, Raghid; Chemaitelly, Hiam; Coyle, Peter; Tang, Patrick; Hasan, Mohammad R; ... more authors ... less authors ( International Society of Global Health , 2022 , Article)

Background: The effective reproduction number, Rt, is a tool to track and understand epidemic dynamics. This investigation of Rt estimations was conducted to guide the national COVID-19 response in Qatar, from the onset ...

Protection of Omicron sub-lineage infection against reinfection with another Omicron sub-lineage

Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; Yassine, Hadi M.; ... more authors ... less authors ( Nature Research , 2022 , Article)

There is significant genetic distance between SARS-CoV-2 Omicron (B.1.1.529) variant BA.1 and BA.2 sub-lineages. This study investigates immune protection of infection with one sub-lineage against reinfection with the other ...

Estimating protection afforded by prior infection in preventing reinfection: Applying the test-negative study design.

Ayoub, Houssein H; Tomy, Milan; Chemaitelly, Hiam; Altarawneh, Heba N; Coyle, Peter; ... more authors ... less authors ( Oxford University Press , 2023 , Article)

The COVID-19 pandemic has highlighted the need to use infection testing databases to rapidly estimate effectiveness of prior infection in preventing reinfection ($P{E}_S$) by novel SARS-CoV-2 variants. Mathematical modeling ...

Rates of recurrent positive SARS-CoV-2 swab results among patients attending primary care in Qatar

Hamed, Ehab; Sedeeq, Saad; Alnuaimi, Ahmed Sameer; Syed, Mohamed; ElHamid, Mohamed Abd; ... more authors ... less authors ( Elsevier , 2021 , Article)

We read with interest the work of COCOREC (Collaborative study COvid RECurrences) study group.1 Recurrent positive rt-PCR results for SARS-CoV-2 infection were reported from early in the epidemic.1 , 2 , 3 , 4 , ...