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VISUALIZATION OF FACTOR VIII WITH FLOW-CYTOMETRY AS A TOOL FOR NOVEL GENE THERAPY APPROACH IN HEMOPHILIA A
(Biomedical Sciences, 2019 , Master Thesis)
Haemophilia A is a genetic X-linked disorder, characterized by coagulation Factor VIII (FVIII) deficiency and leading to pathological bleedings. The disease occurs in a rate of 1 in 5000 males’ births. The treatment is the ...
ANTI-CANCER ACTIVITY OF SANGUINARINE ON HUMAN PAPILLARY THYROID CANCER CELL LINES BY TARGETING JAK/STAT3 PATHWAY
(Biomedical Sciences, 2021 , Master Thesis)
Background: Papillary thyroid carcinoma is the furthermost common type of thyroid
cancer, representing 85 % of all thyroid cancer cases. It occurs more frequently in
women and usually affects 20-55 year age group. Aim: ...
Prevalence of Early Opioid Prescribing for Non-Specific Low Back Pain and Disability Duration: A Systematic Review and Meta-Analysis
(Public Health, 2021 , Master Thesis)
Background: Low back pain (LBP) is a major public health issue, which affects most
people at some point in their lives. LBP poses huge burden on the society in terms of
economic burden because of workdays lost due to ...
Incidence and Prevalence of Hospital Acquired Pressure Injuries (HAPI) in Pediatric population - A Systematic Review and Meta-Analysis
(Public Health, 2021 , Master Thesis)
Background: Hospital acquired pressure injury (HAPI) is a serious patient safety issue
that adversely affects patient's well-being and increases healthcare costs dramatically.
Prevalence and incidence studies estimate ...
Prevalence of Asymptomatic Carotid Artery Stenosis in Patients with Ischemic Heart Disease: A Systematic Review and Meta-analysis
(Public Health, 2021 , Master Thesis)
Background: The coexistence of carotid artery disease in patients undergoing
Coronary artery bypass graft (CABG) is a risk factor for stroke and death. Moreover,
significant carotid artery disease in ischemic heart disease ...
Latent Tuberculosis Infection Among Health Care Workers At The Communicable Disease Center In Qatar: Prevalence And Determinants
(Biomedical Sciences, 2019 , Master Thesis)
Background: To estimate the prevalence of latent Pulmonary Tuberculosis infection among healthcare workers in Communicable Disease Center (CDC) in Qatar and explore the factors associated with latent tuberculosis infection ...
NASAL EXPRESSION OF ANIOTENSIN-CONVERTING ENZYME 2 (ACE2) IN CHILDREN AND ADULTS WITH COVID-19
(Biomedical Sciences, 2021 , Master Thesis)
"Emerging evidence suggests that the lower expression of SARS-CoV-2 entry factor angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) in the nasal epithelium of children may contribute to ...
DEVELOPMENT AND IN VIVO TESTING OF SMART NANOPARTICLES FOR ENHANCED ANTI-CANCER ACTIVITY AND REDUCED CARDIOTOXICITY ASSOCIATED WITH TYROSINE KINASE INHIBITORS
(Biomedical Sciences, 2021 , Master Thesis)
Tyrosine kinase inhibitors (TKIs) are new generation of anti-cancer drugs with very high efficiency against cancer cells. However, TKIs are associated with severe cardiotoxicity limiting their clinical benefits. One ...
THE IMPACT OF HSA-MIR-146A-5P ON HUMAN RETINAL ENDOTHELIAL CELLS IN DIABETIC CONDITIONS
(Biomedical Sciences, 2021 , Master Thesis)
Background: Diabetic retinopathy (DR) is a microvascular complication of diabetes that leads to visual impairment in the adult population with effective available therapy. Micro-Ribonucleic acids (miRNAs) are small (?22 ...
GENERATION AND CHARACTERIZATION OF "OFF-THE-SHELF" CHIMERIC ANTIGEN RECEPTOR ENGINEERED T CELLS (CAR-T) TO TARGET CANCER PATIENTS WITH HEMATOLOGICAL MALIGNANCIES
(Biomedical Sciences, 2021 , Master Thesis)
Background: The usage of T cells engineered with a tumor-specific chimeric antigen receptor (CAR) for the therapeutic treatment of some types of hematological malignancies demonstrated great clinical success. However, the ...