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AuthorDaou, Anis
AuthorAlany, Raid G.
AuthorCalabrese, Gianpiero
Available date2023-10-10T10:06:01Z
Publication Date2021-11-14
Publication NameApplied Sciences (Switzerland)
Identifierhttp://dx.doi.org/10.3390/app112210738
CitationDaou, Anis, Raid G. Alany, and Gianpiero Calabrese. "Formulation of boron encapsulated smart nanocapsules for targeted drug delivery to the brain." Applied Sciences 11.22 (2021): 10738.
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85119602686&origin=inward
URIhttp://hdl.handle.net/10576/48396
AbstractDrug delivery through the Blood–Brain Barrier (BBB) represents a significant challenge. Despite the current strategies to circumvent the BBB, nanotechnology offers unprecedented opportunities for combining selective delivery, improved bioavailability, drug protection, and enhanced pharmacokinetics profiles. Chitosan nanocarriers allow for a more efficacious strategy at the cellular and sub-cellular levels. Boron Neutron Capture Therapy (BNCT) is a targeted chemo-radiotherapeutic technique that allows the selective depletion of cancer cells by means of selective tagging of cancer cells with10B, followed by irradiation with low-energy neutrons. Consequently, the combination of a polymer-based nanodelivery system enclosing an effective BNCT pharmacophore can potentially lead to the selective delivery of the load to cancer cells beyond the BBB. In this work, synthesized novel boronated agents based on carborane-functionalized Delocalized Lipophilic Cations (DLCs) are assessed for safety and selective targeting of tumour cells. The compounds are then encapsulated in nanocarriers constituted by chitosan to promote permeability through the BBB. Additionally, chitosan was used in combination with polypyrrole to form a smart composite nanocapsule, which is expected to release its drug load with variations in pH. Results indicate the achievement of more selective boron delivery to cells via carboranyl DLCs. Finally, preliminary cell studies indicate no toxicity was detected in chitosan nanocapsules, further enhancing its viability as a potential delivery vehicle in the BNCT of brain tumours.
Languageen
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
SubjectBlood–brain barrier
Boron neutron capture therapy
Brain tumours
Delocalised lipophilic cations
Drug delivery
Selective delivery
Smart composite nanodelivery systems
TitleFormulation of boron encapsulated smart nanocapsules for targeted drug delivery to the brain
TypeArticle
Issue Number22
Volume Number11
ESSN2076-3417
dc.accessType Open Access


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