عرض بسيط للتسجيلة

المؤلفVono, Rosa
المؤلفFuoco, Claudio
المؤلفTesta, Stefano
المؤلفPirrò, Stefano
المؤلفMaselli, Davide
المؤلفMcCollough, David Ferland
المؤلفSangalli, Elena
المؤلفPintus, Gianfranco
المؤلفGiordo, Roberta
المؤلفFinzi, Giovanna
المؤلفSessa, Fausto
المؤلفCardani, Rosanna
المؤلفGotti, Ambra
المؤلفLosa, Sergio
المؤلفCesareni, Gianni
المؤلفRizzi, Roberto
المؤلفBearzi, Claudia
المؤلفCannata, Stefano
المؤلفSpinetti, Gaia
المؤلفGargioli, Cesare
المؤلفMadeddu, Paolo
تاريخ الإتاحة2016-10-16T06:35:43Z
تاريخ النشر2016-09
اسم المنشورDiabetes
المعرّفhttp://dx.doi.org/10.2337/db16-0248
الاقتباس"Activation of the Pro-Oxidant PKCβII-p66Shc Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Diabetic Patients with Critical Limb Ischemia" Rosa Vono, Claudia Fuoco, Stefano Testa, Stefano Pirrò, Davide Maselli, David Ferland Mc Collough, Elena Sangalli, Gianfranco Pintus, et al. Diabetes Sep 2016, db160248
الرقم المعياري الدولي للكتاب0012-1797
معرّف المصادر الموحدhttp://hdl.handle.net/10576/4885
الملخصCritical limb ischemia (CLI), foot ulcers, former amputation and impaired regeneration are independent risk factors for limb amputation in diabetic subjects. The present work investigates whether and by which mechanism diabetes negatively impacts on functional properties of muscular pericytes (MPs), which are resident stem cells committed to reparative angiomyogenesis. We obtained muscle biopsies from diabetic patients undergoing major limb amputation and control subjects. Diabetic muscles collected at the rim of normal tissue surrounding the plane of dissection showed myofibres degeneration, fat deposition, and reduction of MPs vascular coverage. Diabetic MPs (D-MPs) display ultrastructural alterations, a differentiation bias towards adipogenesis at the detriment of myogenesis and an inhibitory activity on angiogenesis. Furthermore, they have an imbalanced redox state, with down-regulation of the anti-oxidant enzymes SOD-1 and catalase and activation of the pro-oxidant PKCβII-dependent p66Shc signaling pathway. A reactive oxygen species scavenger or, even more effectively, clinically-approved PKCβII inhibitors restore D-MPs angiomyogenic activity.Inhibition of the PKCβII-dependent p66Shc signaling pathway could represent a novel therapeutic approach for promotion of muscle repair in diabetes.
اللغةen
الناشرAmerican Diabetes Association
الموضوعPericyte
Diabetic Patients
Limb Ischemia
Oxidative Stress
العنوانActivation of the Pro-Oxidant PKCβII-p66Shc Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Diabetic Patients with Critical Limb Ischemia
النوعArticle
ESSN1939-327X
dc.accessType Abstract Only


الملفات في هذه التسجيلة

الملفاتالحجمالصيغةالعرض

لا توجد ملفات لها صلة بهذه التسجيلة.

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة