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AuthorNasser, Mohamad
AuthorAlyamani, Amal A.
AuthorDaou, Anis
AuthorNasser, Malak
AuthorSaad, Zahraa
AuthorHijazi, Akram
AuthorMaresca, Marc
AuthorNasser, Marc
Available date2023-11-02T10:24:22Z
Publication Date2022-08-01
Publication NameProcesses
Identifierhttp://dx.doi.org/10.3390/pr10081461
CitationNasser, M., Alyamani, A. A., Daou, A., Nasser, M., Saad, Z., Hijazi, A., ... & Nasser, M. (2022). Influence of the extraction solvent and of the altitude on the anticancer activity of lebanese eucalyptus camaldulensis extract alone or in combination with low dose of cisplatin in A549 human lung adenocarcinoma cells. Processes, 10(8), 1461.‏
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85137611374&origin=inward
URIhttp://hdl.handle.net/10576/48988
AbstractBackground: Lung cancer is the second most common cancer worldwide. Eucalyptus plant extract has been shown to have anti-neoplastic effects. We investigated the antitumor effect of ethanolic and aqueous extracts of Eucalyptus camaldulensis collected at different altitudes on A549. In addition, we evaluated the additive effect of its combination with low-dose cisplatin (CDDP). Methods: Qualitative and quantitative analyses of secondary metabolites present in the plants were carried out. The antioxidant and cytotoxic activities of the different extracts on A549 were evaluated using the 2.2-diphenyl-1-picrylhydrazyl radical scavenging activity and neutral red assay, respectively. The cytotoxic effect of the combination of certain extract concentrations with low-dose CDDP on A549 cells was studied. Results: In the Ethanoic extract, a higher number of active substances and antioxidant activities were observed. The four E. camaldulensis extracts showed cytotoxic activity on A549 cells, with a higher cytotoxicity for the Ethanoic extract and the sea-level altitude species. Moreover, the dual exposure of cells to both E. camaldulensis extracts and a low dose of Cisplatin showed an additional cytotoxic effect on A549 cells in certain concentrations. Conclusions: This study opens novel therapeutic options in combinational therapies of Eucalyptus camaldulensis with low-dose CDDP for the treatment of adenocarcinoma cells of human lungs.
Languageen
PublisherMDPI
SubjectA549 cells
anti-oxidant effect
anti-tumor effect
cisplatin
cytotoxic effect
Eucalyptus
TitleInfluence of the Extraction Solvent and of the Altitude on the Anticancer Activity of Lebanese Eucalyptus camaldulensis Extract Alone or in Combination with Low Dose of Cisplatin in A549 Human Lung Adenocarcinoma Cells
TypeArticle
Issue Number8
Volume Number10
dc.accessType Open Access


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