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المؤلفKaddoura, Rasha
المؤلفAl-Badriyeh, Daoud
المؤلفAbushanab, Dina
المؤلفAl-Hijji, Mohammed
تاريخ الإتاحة2023-11-05T06:14:28Z
تاريخ النشر2023
اسم المنشورCurrent Problems in Cardiology
المصدرScopus
الرقم المعياري الدولي للكتاب1462806
معرّف المصادر الموحدhttp://dx.doi.org/10.1016/j.cpcardiol.2023.101889
معرّف المصادر الموحدhttp://hdl.handle.net/10576/48996
الملخصMany questions were raised due to the divergent results between cardiovascular outcomes assessment of the MitraClip percutaneous therapy for heart failure patients with functional mitral regurgitation (COAPT) and multicenter study of percutaneous mitral valve Repair MitraClip device in patients with severe secondary mitral regurgitation (MITRA-FR) trials on the use of percutaneous mitral valve repair for secondary mitral regurgitation. This paper examined pooled patients' characteristics and outcomes from real-life experience compared with those in the 2 landmark trials. A comprehensive search identified eligible studies published in 2020 and 2021. Mean difference and odds ratio (OR) were used to compare continuous and categorical data. Thirty-three studies included more than 9200 patients. Patients in landmark trials were younger than in real-life, less likely to present with severe heart failure symptoms ([COAPT: OR 0.25; 95% CI: 0.21, 0.31]; [MITRA-FR: OR 0.32; 95% CI: 0.23, 0.45]) or severe mitral regurgitation grade (COAPT only: OR 0.57; 95% CI: 0.45, 0.71) with larger left ventricular end diastolic volume. Procedure success (OR 1.94; 95% CI: 1.10, 3.40) was more frequent with lower all-cause mortality (OR 0.73; 95% CI: 0.54, 0.99) in COAPT. Real-life patients experienced more favorable procedural and clinical outcomes compared with MITRA-FR patients. Real-life data on percutaneous mitral valve repair in secondary mitral regurgitation showed important variations in patient selection and procedural outcomes. Rates of death and heart failure hospitalization in observational studies were lower than MITRA-FR but higher than COAPT trial.
راعي المشروعFunding: Open access funding provided by the Qatar National Library.
اللغةen
الناشرElsevier
الموضوعMitral-Valve Intervention
Secondary Mitral Regurgitation
Data From Real-Life
العنوانPercutaneous Mitral-Valve Intervention for Secondary Mitral Regurgitation: Data From Real-Life
النوعArticle Review
رقم العدد10
رقم المجلد48
dc.accessType Open Access


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