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AuthorKaddoura, Rasha
AuthorAl-Badriyeh, Daoud
AuthorAbushanab, Dina
AuthorAl-Hijji, Mohammed
Available date2023-11-05T06:14:28Z
Publication Date2023
Publication NameCurrent Problems in Cardiology
ResourceScopus
ISSN1462806
URIhttp://dx.doi.org/10.1016/j.cpcardiol.2023.101889
URIhttp://hdl.handle.net/10576/48996
AbstractMany questions were raised due to the divergent results between cardiovascular outcomes assessment of the MitraClip percutaneous therapy for heart failure patients with functional mitral regurgitation (COAPT) and multicenter study of percutaneous mitral valve Repair MitraClip device in patients with severe secondary mitral regurgitation (MITRA-FR) trials on the use of percutaneous mitral valve repair for secondary mitral regurgitation. This paper examined pooled patients' characteristics and outcomes from real-life experience compared with those in the 2 landmark trials. A comprehensive search identified eligible studies published in 2020 and 2021. Mean difference and odds ratio (OR) were used to compare continuous and categorical data. Thirty-three studies included more than 9200 patients. Patients in landmark trials were younger than in real-life, less likely to present with severe heart failure symptoms ([COAPT: OR 0.25; 95% CI: 0.21, 0.31]; [MITRA-FR: OR 0.32; 95% CI: 0.23, 0.45]) or severe mitral regurgitation grade (COAPT only: OR 0.57; 95% CI: 0.45, 0.71) with larger left ventricular end diastolic volume. Procedure success (OR 1.94; 95% CI: 1.10, 3.40) was more frequent with lower all-cause mortality (OR 0.73; 95% CI: 0.54, 0.99) in COAPT. Real-life patients experienced more favorable procedural and clinical outcomes compared with MITRA-FR patients. Real-life data on percutaneous mitral valve repair in secondary mitral regurgitation showed important variations in patient selection and procedural outcomes. Rates of death and heart failure hospitalization in observational studies were lower than MITRA-FR but higher than COAPT trial.
SponsorFunding: Open access funding provided by the Qatar National Library.
Languageen
PublisherElsevier
SubjectMitral-Valve Intervention
Secondary Mitral Regurgitation
Data From Real-Life
TitlePercutaneous Mitral-Valve Intervention for Secondary Mitral Regurgitation: Data From Real-Life
TypeArticle Review
Issue Number10
Volume Number48
dc.accessType Open Access


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