Short- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study
المؤلف | Hiam, Chemaitelly |
المؤلف | Faust, Jeremy Samuel |
المؤلف | Krumholz, Harlan M. |
المؤلف | Ayoub, Houssein H. |
المؤلف | Tang, Patrick |
المؤلف | Coyle, Peter |
المؤلف | Yassine, Hadi M. |
المؤلف | Al Thani, Asmaa A. |
المؤلف | Al-Khatib, Hebah A. |
المؤلف | Hasan, Mohammad R. |
المؤلف | Al-Kanaani, Zaina |
المؤلف | Al-Kuwari, Einas |
المؤلف | Jeremijenko, Andrew |
المؤلف | Kaleeckal, Anvar Hassan |
المؤلف | Latif, Ali Nizar |
المؤلف | Shaik, Riyazuddin Mohammad |
المؤلف | Abdul-Rahim, Hanan F. |
المؤلف | Nasrallah, Gheyath K. |
المؤلف | Al-Kuwari, Mohamed Ghaith |
المؤلف | Butt, Adeel A. |
المؤلف | Al-Romaihi, Hamad Eid |
المؤلف | Al-Thani, Mohamed H. |
المؤلف | Al-Khal, Abdullatif |
المؤلف | Bertollini, Roberto |
المؤلف | Abu-Raddad, Laith J. |
تاريخ الإتاحة | 2023-11-05T11:00:47Z |
تاريخ النشر | 2023-11-30 |
اسم المنشور | International Journal of Infectious Diseases |
المعرّف | http://dx.doi.org/10.1016/j.ijid.2023.09.005 |
الرقم المعياري الدولي للكتاب | 12019712 |
الملخص | ObjectivesWe assessed short-, medium-, and long-term all-cause mortality risks after a primary SARS-CoV-2 infection. MethodsA national, matched, retrospective cohort study was conducted in Qatar to assess risk of all-cause mortality in the national SARS-CoV-2 primary infection cohort compared with the national infection-naïve cohort. Associations were estimated using Cox proportional-hazards regression models. Analyses were stratified by vaccination status and clinical vulnerability status. ResultsAmong unvaccinated persons, within 90 days after primary infection, the adjusted hazard ratio (aHR) comparing mortality incidence in the primary-infection cohort with the infection-naïve cohort was 1.19 (95% confidence interval 1.02-1.39). aHR was 1.34 (1.11-1.63) in persons more clinically vulnerable to severe COVID-19 and 0.94 (0.72-1.24) in those less clinically vulnerable. Beyond 90 days after primary infection, aHR was 0.50 (0.37-0.68); aHR was 0.41 (0.28-0.58) at 3-7 months and 0.76 (0.46-1.26) at ≥8 months. The aHR was 0.37 (0.25-0.54) in more clinically vulnerable persons and 0.77 (0.48-1.24) in less clinically vulnerable persons. Among vaccinated persons, mortality incidence was comparable in the primary-infection versus infection-naïve cohorts, regardless of clinical vulnerability status. ConclusionsCOVID-19 mortality was primarily driven by an accelerated onset of death among individuals who were already vulnerable to all-cause mortality, but vaccination prevented these accelerated deaths. |
راعي المشروع | The Biomedical Research Program and the Biostatistics, Epidemiology, and the Biomathematics Research Core (both at Weill Cornell Medicine-Qatar), Ministry of Public Health, Hamad Medical Corporation, Sidra Medicine, Qatar Genome Programme, and Qatar University Biomedical Research Center. |
اللغة | en |
الناشر | Elsevier |
الموضوع | COVID-19 Acute infection Immunity Death Long COVID Cohort study Epidemiology |
النوع | Article |
الصفحات | 81-90 |
رقم المجلد | 136 |
Open Access user License | http://creativecommons.org/licenses/by/4.0/ |
ESSN | 1878-3511 |
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