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المؤلفHiam, Chemaitelly
المؤلفFaust, Jeremy Samuel
المؤلفKrumholz, Harlan M.
المؤلفAyoub, Houssein H.
المؤلفTang, Patrick
المؤلفCoyle, Peter
المؤلفYassine, Hadi M.
المؤلفAl Thani, Asmaa A.
المؤلفAl-Khatib, Hebah A.
المؤلفHasan, Mohammad R.
المؤلفAl-Kanaani, Zaina
المؤلفAl-Kuwari, Einas
المؤلفJeremijenko, Andrew
المؤلفKaleeckal, Anvar Hassan
المؤلفLatif, Ali Nizar
المؤلفShaik, Riyazuddin Mohammad
المؤلفAbdul-Rahim, Hanan F.
المؤلفNasrallah, Gheyath K.
المؤلفAl-Kuwari, Mohamed Ghaith
المؤلفButt, Adeel A.
المؤلفAl-Romaihi, Hamad Eid
المؤلفAl-Thani, Mohamed H.
المؤلفAl-Khal, Abdullatif
المؤلفBertollini, Roberto
المؤلفAbu-Raddad, Laith J.
تاريخ الإتاحة2023-11-05T11:00:47Z
تاريخ النشر2023-11-30
اسم المنشورInternational Journal of Infectious Diseases
المعرّفhttp://dx.doi.org/10.1016/j.ijid.2023.09.005
الرقم المعياري الدولي للكتاب12019712
معرّف المصادر الموحدhttps://www.sciencedirect.com/science/article/pii/S1201971223007191
معرّف المصادر الموحدhttp://hdl.handle.net/10576/49028
الملخصObjectivesWe assessed short-, medium-, and long-term all-cause mortality risks after a primary SARS-CoV-2 infection. MethodsA national, matched, retrospective cohort study was conducted in Qatar to assess risk of all-cause mortality in the national SARS-CoV-2 primary infection cohort compared with the national infection-naïve cohort. Associations were estimated using Cox proportional-hazards regression models. Analyses were stratified by vaccination status and clinical vulnerability status. ResultsAmong unvaccinated persons, within 90 days after primary infection, the adjusted hazard ratio (aHR) comparing mortality incidence in the primary-infection cohort with the infection-naïve cohort was 1.19 (95% confidence interval 1.02-1.39). aHR was 1.34 (1.11-1.63) in persons more clinically vulnerable to severe COVID-19 and 0.94 (0.72-1.24) in those less clinically vulnerable. Beyond 90 days after primary infection, aHR was 0.50 (0.37-0.68); aHR was 0.41 (0.28-0.58) at 3-7 months and 0.76 (0.46-1.26) at ≥8 months. The aHR was 0.37 (0.25-0.54) in more clinically vulnerable persons and 0.77 (0.48-1.24) in less clinically vulnerable persons. Among vaccinated persons, mortality incidence was comparable in the primary-infection versus infection-naïve cohorts, regardless of clinical vulnerability status. ConclusionsCOVID-19 mortality was primarily driven by an accelerated onset of death among individuals who were already vulnerable to all-cause mortality, but vaccination prevented these accelerated deaths.
راعي المشروعThe Biomedical Research Program and the Biostatistics, Epidemiology, and the Biomathematics Research Core (both at Weill Cornell Medicine-Qatar), Ministry of Public Health, Hamad Medical Corporation, Sidra Medicine, Qatar Genome Programme, and Qatar University Biomedical Research Center.
اللغةen
الناشرElsevier
الموضوعCOVID-19
Acute infection
Immunity
Death
Long COVID
Cohort study
Epidemiology
العنوانShort- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study
النوعArticle
الصفحات81-90
رقم المجلد136
Open Access user License http://creativecommons.org/licenses/by/4.0/
ESSN1878-3511
dc.accessType Open Access


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