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AuthorHiam, Chemaitelly
AuthorFaust, Jeremy Samuel
AuthorKrumholz, Harlan M.
AuthorAyoub, Houssein H.
AuthorTang, Patrick
AuthorCoyle, Peter
AuthorYassine, Hadi M.
AuthorAl Thani, Asmaa A.
AuthorAl-Khatib, Hebah A.
AuthorHasan, Mohammad R.
AuthorAl-Kanaani, Zaina
AuthorAl-Kuwari, Einas
AuthorJeremijenko, Andrew
AuthorKaleeckal, Anvar Hassan
AuthorLatif, Ali Nizar
AuthorShaik, Riyazuddin Mohammad
AuthorAbdul-Rahim, Hanan F.
AuthorNasrallah, Gheyath K.
AuthorAl-Kuwari, Mohamed Ghaith
AuthorButt, Adeel A.
AuthorAl-Romaihi, Hamad Eid
AuthorAl-Thani, Mohamed H.
AuthorAl-Khal, Abdullatif
AuthorBertollini, Roberto
AuthorAbu-Raddad, Laith J.
Available date2023-11-05T11:00:47Z
Publication Date2023-11-30
Publication NameInternational Journal of Infectious Diseases
Identifierhttp://dx.doi.org/10.1016/j.ijid.2023.09.005
ISSN12019712
URIhttps://www.sciencedirect.com/science/article/pii/S1201971223007191
URIhttp://hdl.handle.net/10576/49028
AbstractObjectivesWe assessed short-, medium-, and long-term all-cause mortality risks after a primary SARS-CoV-2 infection. MethodsA national, matched, retrospective cohort study was conducted in Qatar to assess risk of all-cause mortality in the national SARS-CoV-2 primary infection cohort compared with the national infection-naïve cohort. Associations were estimated using Cox proportional-hazards regression models. Analyses were stratified by vaccination status and clinical vulnerability status. ResultsAmong unvaccinated persons, within 90 days after primary infection, the adjusted hazard ratio (aHR) comparing mortality incidence in the primary-infection cohort with the infection-naïve cohort was 1.19 (95% confidence interval 1.02-1.39). aHR was 1.34 (1.11-1.63) in persons more clinically vulnerable to severe COVID-19 and 0.94 (0.72-1.24) in those less clinically vulnerable. Beyond 90 days after primary infection, aHR was 0.50 (0.37-0.68); aHR was 0.41 (0.28-0.58) at 3-7 months and 0.76 (0.46-1.26) at ≥8 months. The aHR was 0.37 (0.25-0.54) in more clinically vulnerable persons and 0.77 (0.48-1.24) in less clinically vulnerable persons. Among vaccinated persons, mortality incidence was comparable in the primary-infection versus infection-naïve cohorts, regardless of clinical vulnerability status. ConclusionsCOVID-19 mortality was primarily driven by an accelerated onset of death among individuals who were already vulnerable to all-cause mortality, but vaccination prevented these accelerated deaths.
SponsorThe Biomedical Research Program and the Biostatistics, Epidemiology, and the Biomathematics Research Core (both at Weill Cornell Medicine-Qatar), Ministry of Public Health, Hamad Medical Corporation, Sidra Medicine, Qatar Genome Programme, and Qatar University Biomedical Research Center.
Languageen
PublisherElsevier
SubjectCOVID-19
Acute infection
Immunity
Death
Long COVID
Cohort study
Epidemiology
TitleShort- and longer-term all-cause mortality among SARS-CoV-2- infected individuals and the pull-forward phenomenon in Qatar: a national cohort study
TypeArticle
Pagination81-90
Volume Number136
Open Access user License http://creativecommons.org/licenses/by/4.0/
ESSN1878-3511
dc.accessType Open Access


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