A Prospective Cohort Study (OUTSTRIP-COVID) on Functional and Spirometry Outcomes in COVID-19 ICU Survivors at 3 Months
Author | Thomas, Merlin |
Author | Raza, Tasleem |
Author | Hameed, Mansoor |
Author | Sharma, Rohit |
Author | Rajagopal, Rajalekshmi Maheswari |
Author | Adab, Aisha Hussain O.Al |
Author | Ahmad, Mushtaq |
Author | George, Saibu |
Author | Hussein, Mousa |
Author | Akram, Jaweria |
Author | Ibrahim, Mohamed Izham Mohamed |
Author | Hssain, Ali Ait |
Author | Yousaf, Muhammad |
Author | Khatib, Mohamad Yahya |
Available date | 2023-11-12T07:16:58Z |
Publication Date | 2023-01-01 |
Publication Name | International Journal of General Medicine |
Identifier | http://dx.doi.org/10.2147/IJGM.S404834 |
Citation | Thomas, M., Raza, T., Hameed, M., Sharma, R., Rajagopal, R. M., Hussain O Al Adab, A., ... & Yahya Khatib, M. (2023). A Prospective Cohort Study (OUTSTRIP-COVID) on Functional and Spirometry Outcomes in COVID-19 ICU Survivors at 3 Months. International Journal of General Medicine, 2633-2642. |
Abstract | Purpose: COVID-19 pandemic resulted in a significant number of critical care admissions secondary to severe pneumonia and acute respiratory distress syndrome. We evaluated the short-, medium-and long-term outcomes of lung function and quality of life in this prospective cohort study and reported the outcomes at 7 weeks and 3 months from discharge from intensive care unit. Methods: A prospective cohort study of ICU survivors with COVID-19 was conducted from August 2020 to May 2021 to evaluate baseline demographic and clinical variables as well as determine lung function, exercise capacity, and health-related quality of life (HRQOL) using spirometry and 6-minute walk test (6MWT) conducted in accordance with American Thoracic Society standards, and SF-36 (Rand), respectively. SF-36 is a generic 36 question standardized health survey. Descriptive and inferential statistics (alpha = 0.05) were used to analyse the data. Results: At baseline, 100 participants were enrolled in the study of whom 76 followed up at 3 months. Majority of the patients were male (83%), Asians (84%) and less than 60 years of age (91%). HRQOL showed significant improvement in all domains of SF-36, except in emotional wellbeing. Spirometry variables also showed significant improvement in all variables over time with greatest improvement in percentage predicted Forced expiratory volume 1 (79% vs 88% p < 0.001). 6MWT showed significant improvement in variables of walk distance, dyspnea, and fatigue with greatest improvement in change in oxygen saturation (3% vs 1.44% p < 0.001). Intubation status did not impact the changes in SF-36, spirometry or 6MWT variables. Conclusion: Our findings suggest that ICU survivors of COVID-19 have significant improvement in their lung function, exercise capacity and HRQOL within 3 months of ICU discharge regardless of intubation status. |
Language | en |
Publisher | Taylor & Francis Group |
Subject | COVID-19 exercise capacity health related quality of life lung function |
Type | Article |
Volume Number | 16 |
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COVID-19 Research [818 items ]
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