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AuthorThomas, Merlin
AuthorRaza, Tasleem
AuthorHameed, Mansoor
AuthorSharma, Rohit
AuthorRajagopal, Rajalekshmi Maheswari
AuthorAdab, Aisha Hussain O.Al
AuthorAhmad, Mushtaq
AuthorGeorge, Saibu
AuthorHussein, Mousa
AuthorAkram, Jaweria
AuthorIbrahim, Mohamed Izham Mohamed
AuthorHssain, Ali Ait
AuthorYousaf, Muhammad
AuthorKhatib, Mohamad Yahya
Available date2023-11-12T07:16:58Z
Publication Date2023-01-01
Publication NameInternational Journal of General Medicine
Identifierhttp://dx.doi.org/10.2147/IJGM.S404834
CitationThomas, M., Raza, T., Hameed, M., Sharma, R., Rajagopal, R. M., Hussain O Al Adab, A., ... & Yahya Khatib, M. (2023). A Prospective Cohort Study (OUTSTRIP-COVID) on Functional and Spirometry Outcomes in COVID-19 ICU Survivors at 3 Months. International Journal of General Medicine, 2633-2642.‏
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85163574801&origin=inward
URIhttp://hdl.handle.net/10576/49169
AbstractPurpose: COVID-19 pandemic resulted in a significant number of critical care admissions secondary to severe pneumonia and acute respiratory distress syndrome. We evaluated the short-, medium-and long-term outcomes of lung function and quality of life in this prospective cohort study and reported the outcomes at 7 weeks and 3 months from discharge from intensive care unit. Methods: A prospective cohort study of ICU survivors with COVID-19 was conducted from August 2020 to May 2021 to evaluate baseline demographic and clinical variables as well as determine lung function, exercise capacity, and health-related quality of life (HRQOL) using spirometry and 6-minute walk test (6MWT) conducted in accordance with American Thoracic Society standards, and SF-36 (Rand), respectively. SF-36 is a generic 36 question standardized health survey. Descriptive and inferential statistics (alpha = 0.05) were used to analyse the data. Results: At baseline, 100 participants were enrolled in the study of whom 76 followed up at 3 months. Majority of the patients were male (83%), Asians (84%) and less than 60 years of age (91%). HRQOL showed significant improvement in all domains of SF-36, except in emotional wellbeing. Spirometry variables also showed significant improvement in all variables over time with greatest improvement in percentage predicted Forced expiratory volume 1 (79% vs 88% p < 0.001). 6MWT showed significant improvement in variables of walk distance, dyspnea, and fatigue with greatest improvement in change in oxygen saturation (3% vs 1.44% p < 0.001). Intubation status did not impact the changes in SF-36, spirometry or 6MWT variables. Conclusion: Our findings suggest that ICU survivors of COVID-19 have significant improvement in their lung function, exercise capacity and HRQOL within 3 months of ICU discharge regardless of intubation status.
Languageen
PublisherTaylor & Francis Group
SubjectCOVID-19
exercise capacity
health related quality of life
lung function
TitleA Prospective Cohort Study (OUTSTRIP-COVID) on Functional and Spirometry Outcomes in COVID-19 ICU Survivors at 3 Months
TypeArticle
Volume Number16
dc.accessType Abstract Only


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