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المؤلفMohamed, Iman A.
المؤلفKrishnamoorthy, Navaneethakrishnan T.
المؤلفNasrallah, Gheyath K.
المؤلفDa'as, Sahar
تاريخ الإتاحة2016-10-26T06:32:01Z
تاريخ النشر2016-10-12
اسم المنشورJournal of Cellular Physiology
المعرّفhttp://dx.doi.org/10.1002/jcp.25639
الاقتباسMohamed, I. A., Krishnamoorthy, N. T., Nasrallah, G. K. and Da'as, S. (2016), The Role of Cardiac Myosin Binding Protein C3 in Hypertrophic Cardiomyopathy- Progress and Novel Therapeutic Opportunities. J. Cell. Physiol.. Accepted Author Manuscript.
الرقم المعياري الدولي للكتاب0021-9541
معرّف المصادر الموحدhttp://hdl.handle.net/10576/4924
الملخصHypertrophic cardiomyopathy (HCM) is a common autosomal dominant genetic cardiovascular disorder marked by genetic and phenotypic heterogeneity. Mutations in the gene encodes the cardiac myosin-binding protein C, cMYBPC3 is amongst the various sarcomeric genes that are associated with HCM. These mutations produce mutated mRNAs and truncated cMyBP-C proteins. In this review, we will discuss the implications and molecular mechanisms involved in MYBPC3 different mutations. Further, we will highlight the novel targets that can be developed into potential therapeutics for the treatment of HMC. This article is protected by copyright. All rights reserved
اللغةen
الناشرWiley
الموضوعMyosin
Cardiomyopathy
Hypertrophy
العنوانThe Role of Cardiac Myosin Binding Protein C3 in Hypertrophic Cardiomyopathy- Progress and Novel Therapeutic Opportunities
النوعArticle
ESSN1097-4652
dc.accessType Open Access


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