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AuthorMohamed, Iman A.
AuthorKrishnamoorthy, Navaneethakrishnan T.
AuthorNasrallah, Gheyath K.
AuthorDa'as, Sahar
Available date2016-10-26T06:32:01Z
Publication Date2016-10-12
Publication NameJournal of Cellular Physiology
Identifierhttp://dx.doi.org/10.1002/jcp.25639
CitationMohamed, I. A., Krishnamoorthy, N. T., Nasrallah, G. K. and Da'as, S. (2016), The Role of Cardiac Myosin Binding Protein C3 in Hypertrophic Cardiomyopathy- Progress and Novel Therapeutic Opportunities. J. Cell. Physiol.. Accepted Author Manuscript.
ISSN0021-9541
URIhttp://hdl.handle.net/10576/4924
AbstractHypertrophic cardiomyopathy (HCM) is a common autosomal dominant genetic cardiovascular disorder marked by genetic and phenotypic heterogeneity. Mutations in the gene encodes the cardiac myosin-binding protein C, cMYBPC3 is amongst the various sarcomeric genes that are associated with HCM. These mutations produce mutated mRNAs and truncated cMyBP-C proteins. In this review, we will discuss the implications and molecular mechanisms involved in MYBPC3 different mutations. Further, we will highlight the novel targets that can be developed into potential therapeutics for the treatment of HMC. This article is protected by copyright. All rights reserved
Languageen
PublisherWiley
SubjectMyosin
Cardiomyopathy
Hypertrophy
TitleThe Role of Cardiac Myosin Binding Protein C3 in Hypertrophic Cardiomyopathy- Progress and Novel Therapeutic Opportunities
TypeArticle
ESSN1097-4652
dc.accessType Open Access


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