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المؤلفAhmed, Ali
المؤلفDujaili, Juman A.
المؤلفChuah, Lay H.
المؤلفHashmi, Furqan K.
المؤلفLe, Long K.
المؤلفChatha, Zeenat F.
المؤلفKhanal, Saval
المؤلفAwaisu, Ahmed
المؤلفChaiyakunapruk, Nathorn
تاريخ الإتاحة2023-11-19T05:45:34Z
تاريخ النشر2023
اسم المنشورHealthcare (Switzerland)
المصدرScopus
الرقم المعياري الدولي للكتاب22279032
معرّف المصادر الموحدhttp://dx.doi.org/10.3390/healthcare11172453
معرّف المصادر الموحدhttp://hdl.handle.net/10576/49429
الملخصBackground: Evidence has shown the positive impact of pharmacist involvement on the adherence and health outcomes of people living with HIV/AIDS. However, whether such intervention provides value for money remains unclear. This study aims to fill this gap by assessing the cost-effectiveness of pharmacist interventions in HIV care in Pakistan. Methods: A Markov decision analytic model was constructed, considering clinical inputs, utility data, and cost data obtained from a randomized controlled trial and an HIV cohort of Pakistani origin. The analysis was conducted from a healthcare perspective, and the incremental cost-effectiveness ratio (ICER) was calculated and presented for the year 2023. Additionally, a series of sensitivity analyses were performed to assess the robustness of the results. Results: Pharmacist intervention resulted in higher quality-adjusted life years (4.05 vs. 2.93) and likewise higher annual intervention costs than usual care (1979 USD vs. 429 USD) (532,894 PKR vs. 115,518 PKR). This yielded the ICER of 1383 USD/quality-adjusted life years (QALY) (372,406 PKR/QALY), which is well below the willingness-to-pay threshold of 1658 USD (446,456 PKR/QALY) recommended by the World Health Organization Choosing Interventions that are Cost-Effective. Probabilistic sensitivity analysis reported that more than 68% of iterations were below the lower limit of threshold. Sensitivity analysis reported intervention cost is the most important parameter influencing the ICER the most. Conclusion: The study suggests that involving pharmacists in HIV care could be a cost-effective approach. These findings could help shape healthcare policies and plans, possibly making pharmacist interventions a regular part of care for people with HIV in Pakistan.
اللغةen
الناشرMDPI
الموضوعadherence
cost-effectiveness
health outcomes
incremental cost-effectiveness ratio
Pakistan
pharmacist
العنوانCost-Effectiveness Analysis of Pharmacist Adherence Interventions in People Living with HIV/AIDS in Pakistan
النوعArticle
رقم العدد17
رقم المجلد11
dc.accessType Open Access


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