Genome-wide association study identifies several loci for HEV seropositivity
المؤلف | Maria K., Smatti |
المؤلف | Al-Sarraj, Yasser A. |
المؤلف | Albagha, Omar |
المؤلف | Yassine, Hadi M. |
تاريخ الإتاحة | 2023-12-04T06:28:58Z |
تاريخ النشر | 2023-09-15 |
اسم المنشور | iScience |
المعرّف | http://dx.doi.org/10.1016/j.isci.2023.107586 |
الرقم المعياري الدولي للكتاب | 25890042 |
الملخص | Hepatitis E viral (HEV) infection imposes a heavy global health burden. The variability in the prevalence of serological markers of HEV infection between different ethnic groups proposes a host genetic influence. Here, we report genetic polymorphisms associated with anti-HEV antibody positivity and level using binary- and quantitative-trait genome-wide association studies (GWAS) on a population from Qatar (n = 5829). We identified a region in 12p11.1 (lead SNP: rs559856097, allele: A, p = 2.3 × 10−10) significantly associated with anti-HEV antibodies level. This intergenic variant is located near SNORD112, a small nucleolar RNA (snoRNA). Additional gene-set and pathway enrichment analyses highlighted a strong correlation with anti-viral response-related pathways, including IFNs (alpha/beta) and interleukin-21 (IL-21) signaling. This is the first GWAS on the response to HEV infection. Further replication and functional experimentation are warranted to validate these findings. |
راعي المشروع | This study was funded by Qatar University High Impact Grant (Grant number: QUHI-BRC-20_21-1). The work makes use of data generated by the Qatar Genome Program (QGP) and Qatar Biobank (QBB), which are funded by Qatar foundation for Education, Science and Community. |
اللغة | en |
الناشر | Elsevier |
الموضوع | Association analysis Immune response Quantitative genetics Virology |
النوع | Article |
رقم العدد | 9 |
رقم المجلد | 26 |
Open Access user License | http://creativecommons.org/licenses/by/4.0/ |
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