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المؤلفMaria K., Smatti
المؤلفAl-Sarraj, Yasser A.
المؤلفAlbagha, Omar
المؤلفYassine, Hadi M.
تاريخ الإتاحة2023-12-04T06:28:58Z
تاريخ النشر2023-09-15
اسم المنشورiScience
المعرّفhttp://dx.doi.org/10.1016/j.isci.2023.107586
الرقم المعياري الدولي للكتاب25890042
معرّف المصادر الموحدhttps://www.sciencedirect.com/science/article/pii/S2589004223016632
معرّف المصادر الموحدhttp://hdl.handle.net/10576/50062
الملخصHepatitis E viral (HEV) infection imposes a heavy global health burden. The variability in the prevalence of serological markers of HEV infection between different ethnic groups proposes a host genetic influence. Here, we report genetic polymorphisms associated with anti-HEV antibody positivity and level using binary- and quantitative-trait genome-wide association studies (GWAS) on a population from Qatar (n = 5829). We identified a region in 12p11.1 (lead SNP: rs559856097, allele: A, p = 2.3 × 10−10) significantly associated with anti-HEV antibodies level. This intergenic variant is located near SNORD112, a small nucleolar RNA (snoRNA). Additional gene-set and pathway enrichment analyses highlighted a strong correlation with anti-viral response-related pathways, including IFNs (alpha/beta) and interleukin-21 (IL-21) signaling. This is the first GWAS on the response to HEV infection. Further replication and functional experimentation are warranted to validate these findings.
راعي المشروعThis study was funded by Qatar University High Impact Grant (Grant number: QUHI-BRC-20_21-1). The work makes use of data generated by the Qatar Genome Program (QGP) and Qatar Biobank (QBB), which are funded by Qatar foundation for Education, Science and Community.
اللغةen
الناشرElsevier
الموضوعAssociation analysis
Immune response
Quantitative genetics
Virology
العنوانGenome-wide association study identifies several loci for HEV seropositivity
النوعArticle
رقم العدد9
رقم المجلد26
Open Access user License http://creativecommons.org/licenses/by/4.0/
dc.accessType Open Access


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