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AuthorMaria K., Smatti
AuthorAl-Sarraj, Yasser A.
AuthorAlbagha, Omar
AuthorYassine, Hadi M.
Available date2023-12-04T06:28:58Z
Publication Date2023-09-15
Publication NameiScience
Identifierhttp://dx.doi.org/10.1016/j.isci.2023.107586
ISSN25890042
URIhttps://www.sciencedirect.com/science/article/pii/S2589004223016632
URIhttp://hdl.handle.net/10576/50062
AbstractHepatitis E viral (HEV) infection imposes a heavy global health burden. The variability in the prevalence of serological markers of HEV infection between different ethnic groups proposes a host genetic influence. Here, we report genetic polymorphisms associated with anti-HEV antibody positivity and level using binary- and quantitative-trait genome-wide association studies (GWAS) on a population from Qatar (n = 5829). We identified a region in 12p11.1 (lead SNP: rs559856097, allele: A, p = 2.3 × 10−10) significantly associated with anti-HEV antibodies level. This intergenic variant is located near SNORD112, a small nucleolar RNA (snoRNA). Additional gene-set and pathway enrichment analyses highlighted a strong correlation with anti-viral response-related pathways, including IFNs (alpha/beta) and interleukin-21 (IL-21) signaling. This is the first GWAS on the response to HEV infection. Further replication and functional experimentation are warranted to validate these findings.
SponsorThis study was funded by Qatar University High Impact Grant (Grant number: QUHI-BRC-20_21-1). The work makes use of data generated by the Qatar Genome Program (QGP) and Qatar Biobank (QBB), which are funded by Qatar foundation for Education, Science and Community.
Languageen
PublisherElsevier
SubjectAssociation analysis
Immune response
Quantitative genetics
Virology
TitleGenome-wide association study identifies several loci for HEV seropositivity
TypeArticle
Issue Number9
Volume Number26
Open Access user License http://creativecommons.org/licenses/by/4.0/
dc.accessType Open Access


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