Regulatory Mechanisms That Guide the Fetal to Postnatal Transition of Cardiomyocytes
Author | Burgon, Patrick G. |
Author | Weldrick, Jonathan J. |
Author | Talab, Omar Mohamed Sayed Ahmed |
Author | Nadeer, Muhammad |
Author | Nomikos, Michail |
Author | Megeney, Lynn A. |
Available date | 2024-01-29T10:26:10Z |
Publication Date | 2023-09-21 |
Publication Name | Cells |
Identifier | http://dx.doi.org/10.3390/cells12182324 |
Citation | Burgon, P. G., Weldrick, J. J., Talab, O. M. S. A., Nadeer, M., Nomikos, M., & Megeney, L. A. (2023). Regulatory Mechanisms That Guide the Fetal to Postnatal Transition of Cardiomyocytes. Cells, 12(18), 2324. |
Abstract | Heart disease remains a global leading cause of death and disability, necessitating a comprehensive understanding of the heart’s development, repair, and dysfunction. This review surveys recent discoveries that explore the developmental transition of proliferative fetal cardiomyocytes into hypertrophic postnatal cardiomyocytes, a process yet to be well-defined. This transition is key to the heart’s growth and has promising therapeutic potential, particularly for congenital or acquired heart damage, such as myocardial infarctions. Although significant progress has been made, much work is needed to unravel the complex interplay of signaling pathways that regulate cardiomyocyte proliferation and hypertrophy. This review provides a detailed perspective for future research directions aimed at the potential therapeutic harnessing of the perinatal heart transitions. |
Sponsor | - QU Internal Grant [QUST-2-CMED-2021-204]. - Qatar University Collaborative Grant [QUCG-CAS-23/24-214]. - QU Internal Grant [QUCG-CMED-22/23-514]. - Canadian Institute of Health Research Funding [#169089]. - Queen Elizabeth II Graduate Scholarship (QEII-GSST) - University of Ottawa Excellence Scholarship. |
Language | en |
Publisher | Multidisciplinary Digital Publishing Institute (MDPI) |
Subject | fetal to postnatal development hypertrophy and proliferation micro-RNA signaling pathways (mTOR, Hippo, YAP/TAZ) therapeutic potential |
Type | Article |
Issue Number | 18 |
Volume Number | 12 |
ESSN | 2073-4409 |
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