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المؤلفZolezzi, Monica
المؤلفElhakim, Athar
المؤلفQubaiah, Iman A.
المؤلفHoms, Shorouq
المؤلفElamin, Waad
المؤلفTawfik, Engy Sherif
المؤلفAl-Khuzaei, Noriya
المؤلفMahmoud, Doaa Elsayed
المؤلفAbdallah, Oraib
المؤلفEltorki, Yassin
تاريخ الإتاحة2024-01-30T08:33:09Z
تاريخ النشر2023-10-13
اسم المنشورRisk Management and Healthcare Policy
المعرّفhttp://dx.doi.org/10.2147/RMHP.S426591
الاقتباسZolezzi, M., Elhakim, A., Qubaiah, I. A., Mahmoud, D. E., Homs, S., Elamin, W., ... & Al-Khuzaei, N. (2023). Assessment of Drug-Induced QTc Prolongation in Mental Health Practice: Validation of an Evidence-Based Algorithm. Risk Management and Healthcare Policy, 2113-2124.
الرقم المعياري الدولي للكتاب1179-1594
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85174564929&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/51354
الملخصBackground: Drug-induced QTc interval prolongation (QTcIP) can lead to serious consequences and is often a concern for mental health practitioners, as access to experts such as cardiologists, for consultation is time-limiting and can delay treatment decisions. This research aimed at validating the content of an algorithm for the assessment, management and monitoring of drug-induced QTcIP in mental health practice. Methods: Following an initial face validity by content experts, a cross-sectional survey of mental health care practitioners with a 4-point Likert-type scale was used to assess the validity of the decision steps on the QTcIP algorithm (QTcIPA) by estimating the content validity index (CVI) and the modified kappa statistic (κ*). Participants’ open-ended comments were also thematically analyzed. Results: Mental health practitioners found the QTcIPA to be appropriate, safe, and evidence-based, as indicated by the high individual item CVI scores ranging from 0.89 to 1 for all of the steps/decision statements in the three domains assessed: appropriateness, safety and reliability of the references used. Five themes emerged from the qualitative analysis of the open-ended comments, of which three were identified as strengths, including practical usability, reliable references and beneficial for pharmacists. Two themes were recognized as limitations, namely, the need for additional clinical content and application barriers. Conclusion: These results suggest that the QTcIPA may be a useful tool for mental health clinicians at the time of prescribing medications with potential risk of QTcIP. Future research will explore the implementation of the QTcIPA into clinical practice using computerized decision support tools through web-based and mobile applications.
راعي المشروعThis study was made possible by the Undergraduate Research Experience Program (UREP) grant (UREP24-041-3-016) of the Qatar National Research Foundation and Qatar University Student Grant (QUST-2-CPH-2019-17). Publication funding was provided by Qatar University High Impact Grant (QUHI-CPH-23/24-161).
اللغةen
الناشرDove Medical Press
الموضوعalgorithm
clinical decision tool
drug-induced arrhythmias
mental health practice
QTc interval prolongation
العنوانAssessment of Drug-Induced QTc Prolongation in Mental Health Practice: Validation of an Evidence-Based Algorithm
النوعArticle
الصفحات2113-2124
رقم المجلد16
dc.accessType Open Access


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