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AuthorZolezzi, Monica
AuthorElhakim, Athar
AuthorQubaiah, Iman A.
AuthorHoms, Shorouq
AuthorElamin, Waad
AuthorTawfik, Engy Sherif
AuthorAl-Khuzaei, Noriya
AuthorMahmoud, Doaa Elsayed
AuthorAbdallah, Oraib
AuthorEltorki, Yassin
Available date2024-01-30T08:33:09Z
Publication Date2023-10-13
Publication NameRisk Management and Healthcare Policy
Identifierhttp://dx.doi.org/10.2147/RMHP.S426591
CitationZolezzi, M., Elhakim, A., Qubaiah, I. A., Mahmoud, D. E., Homs, S., Elamin, W., ... & Al-Khuzaei, N. (2023). Assessment of Drug-Induced QTc Prolongation in Mental Health Practice: Validation of an Evidence-Based Algorithm. Risk Management and Healthcare Policy, 2113-2124.
ISSN1179-1594
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85174564929&origin=inward
URIhttp://hdl.handle.net/10576/51354
AbstractBackground: Drug-induced QTc interval prolongation (QTcIP) can lead to serious consequences and is often a concern for mental health practitioners, as access to experts such as cardiologists, for consultation is time-limiting and can delay treatment decisions. This research aimed at validating the content of an algorithm for the assessment, management and monitoring of drug-induced QTcIP in mental health practice. Methods: Following an initial face validity by content experts, a cross-sectional survey of mental health care practitioners with a 4-point Likert-type scale was used to assess the validity of the decision steps on the QTcIP algorithm (QTcIPA) by estimating the content validity index (CVI) and the modified kappa statistic (κ*). Participants’ open-ended comments were also thematically analyzed. Results: Mental health practitioners found the QTcIPA to be appropriate, safe, and evidence-based, as indicated by the high individual item CVI scores ranging from 0.89 to 1 for all of the steps/decision statements in the three domains assessed: appropriateness, safety and reliability of the references used. Five themes emerged from the qualitative analysis of the open-ended comments, of which three were identified as strengths, including practical usability, reliable references and beneficial for pharmacists. Two themes were recognized as limitations, namely, the need for additional clinical content and application barriers. Conclusion: These results suggest that the QTcIPA may be a useful tool for mental health clinicians at the time of prescribing medications with potential risk of QTcIP. Future research will explore the implementation of the QTcIPA into clinical practice using computerized decision support tools through web-based and mobile applications.
SponsorThis study was made possible by the Undergraduate Research Experience Program (UREP) grant (UREP24-041-3-016) of the Qatar National Research Foundation and Qatar University Student Grant (QUST-2-CPH-2019-17). Publication funding was provided by Qatar University High Impact Grant (QUHI-CPH-23/24-161).
Languageen
PublisherDove Medical Press
Subjectalgorithm
clinical decision tool
drug-induced arrhythmias
mental health practice
QTc interval prolongation
TitleAssessment of Drug-Induced QTc Prolongation in Mental Health Practice: Validation of an Evidence-Based Algorithm
TypeArticle
Pagination2113-2124
Volume Number16
dc.accessType Open Access


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