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المؤلفKuttikrishnan, Shilpa
المؤلفAhmad, Fareed
المؤلفMateo, Jericha M.
المؤلفPrabhu, Kirti S.
المؤلفEl-Elimat, Tamam
المؤلفOberlies, Nicholas H.
المؤلفPearce, Cedric J.
المؤلفAkil, Ammira S.Alshabeeb
المؤلفBhat, Ajaz A.
المؤلفAlali, Feras Q.
المؤلفUddin, Shahab
تاريخ الإتاحة2024-01-30T11:03:06Z
تاريخ النشر2023-10-26
اسم المنشورCell Biology International
المعرّفhttp://dx.doi.org/10.1002/cbin.12101
الاقتباسKuttikrishnan, S., Ahmad, F., Mateo, J. M., Prabhu, K. S., El‐Elimat, T., Oberlies, N. H., ... & Uddin, S. (2023). Neosetophomone B induces apoptosis in multiple myeloma cells via targeting of AKT/SKP2 signaling pathway. Cell Biology International.
الرقم المعياري الدولي للكتاب1065-6995
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85175040049&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/51388
الملخصMultiple myeloma (MM) is a hematologic malignancy associated with malignant plasma cell proliferation in the bone marrow. Despite the available treatments, drug resistance and adverse side effects pose significant challenges, underscoring the need for alternative therapeutic strategies. Natural products, like the fungal metabolite neosetophomone B (NSP-B), have emerged as potential therapeutic agents due to their bioactive properties. Our study investigated NSP-B's antitumor effects on MM cell lines (U266 and RPMI8226) and the involved molecular mechanisms. NSP-B demonstrated significant growth inhibition and apoptotic induction, triggered by reduced AKT activation and downregulation of the inhibitors of apoptotic proteins and S-phase kinase protein. This was accompanied by an upregulation of p21Kip1 and p27Cip1 and an elevated Bax/BCL2 ratio, culminating in caspase-dependent apoptosis. Interestingly, NSP-B also enhanced the cytotoxicity of bortezomib (BTZ), an existing MM treatment. Overall, our findings demonstrated that NSP-B induces caspase-dependent apoptosis, increases cell damage, and suppresses MM cell proliferation while improving the cytotoxic impact of BTZ. These findings suggest that NSP-B can be used alone or in combination with other medicines to treat MM, highlighting its importance as a promising phytoconstituent in cancer therapy.
راعي المشروعQatar National Library provided open access of this article. This work was supported by grants funded by the Medical Research Center (MRC), Hamad Medical Corporation, Doha, Qatar (MRC‐01‐21‐301).
اللغةen
الناشرWiley-Blackwell
الموضوعAKT
caspases
drug synergy
multiple myeloma
neosetophomone B
SKP2
العنوانNeosetophomone B induces apoptosis in multiple myeloma cells via targeting of AKT/SKP2 signaling pathway
النوعArticle
رقم العدد2
رقم المجلد48
ESSN1095-8355
dc.accessType Open Access


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