Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa
المؤلف | Majdalawieh, Amin F. |
المؤلف | Fayyad, Muneera W. |
المؤلف | Nasrallah, Gheyath K. |
تاريخ الإتاحة | 2017-02-22T05:39:09Z |
تاريخ النشر | 2017 |
اسم المنشور | Critical Reviews in Food Science and Nutrition |
المعرّف | http://dx.doi.org/10.1080/10408398.2016.1277971 |
الاقتباس | Amin F. Majdalawieh, Muneera W. Fayyad & Gheyath K. Nasrallah (2017): Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa, Critical Reviews in Food Science and Nutrition |
الرقم المعياري الدولي للكتاب | 1040-8398 |
الملخص | Over the past two decades, studies have documented the wide-range anti-cancer effects of Nigella sativa, known as black seed or black cumin. Thymoquinone (TQ), its major active ingredient, has also been extensively studied and reported to possess potent anti-cancer properties. Herein, we provide a comprehensive review of the findings related to the anti-cancer activity of TQ. The review focuses on analyzing experimental studies performed using different in vitro and in vivo models to identify the anti-proliferative, pro-apoptotic, anti-oxidant, cytotoxic, anti-metastatic, and NK-dependent cytotoxic effects exerted by TQ. In addition, we pinpoint the molecular mechanisms underlying these effects and the signal transduction pathways implicated by TQ. Our analysis show that p53, NF-κB, PPARγ, STAT3, MAPK, and PI3K/AKT signaling pathways are among the most significant pathways through which TQ mediates its anti-cancer activity. Experimental findings and recent advances in the field highlight TQ as an effective therapeutic agent for the suppression of tumor development, growth and metastasis for a wide range of tumors |
اللغة | en |
الناشر | Taylor & Francis |
الموضوع | Nigella sativa cytotoxicity apoptosis anti-cancer thymoquinone (TQ) |
النوع | Article |
ESSN | 1549-7852 |
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