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AuthorMajdalawieh, Amin F.
AuthorFayyad, Muneera W.
AuthorNasrallah, Gheyath K.
Available date2017-02-22T05:39:09Z
Publication Date2017
Publication NameCritical Reviews in Food Science and Nutrition
Identifierhttp://dx.doi.org/10.1080/10408398.2016.1277971
CitationAmin F. Majdalawieh, Muneera W. Fayyad & Gheyath K. Nasrallah (2017): Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa, Critical Reviews in Food Science and Nutrition
ISSN1040-8398
URIhttp://hdl.handle.net/10576/5293
AbstractOver the past two decades, studies have documented the wide-range anti-cancer effects of Nigella sativa, known as black seed or black cumin. Thymoquinone (TQ), its major active ingredient, has also been extensively studied and reported to possess potent anti-cancer properties. Herein, we provide a comprehensive review of the findings related to the anti-cancer activity of TQ. The review focuses on analyzing experimental studies performed using different in vitro and in vivo models to identify the anti-proliferative, pro-apoptotic, anti-oxidant, cytotoxic, anti-metastatic, and NK-dependent cytotoxic effects exerted by TQ. In addition, we pinpoint the molecular mechanisms underlying these effects and the signal transduction pathways implicated by TQ. Our analysis show that p53, NF-κB, PPARγ, STAT3, MAPK, and PI3K/AKT signaling pathways are among the most significant pathways through which TQ mediates its anti-cancer activity. Experimental findings and recent advances in the field highlight TQ as an effective therapeutic agent for the suppression of tumor development, growth and metastasis for a wide range of tumors
Languageen
PublisherTaylor & Francis
SubjectNigella sativa
cytotoxicity
apoptosis
anti-cancer
thymoquinone (TQ)
TitleAnti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa
TypeArticle
ESSN1549-7852
dc.accessType Open Access


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