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AuthorTurner, Stuart J.
AuthorSenol, Esin
AuthorKara, Ates
AuthorAl-Badriyeh, Daoud
AuthorDinleyici, Ener C.
AuthorKong, David CM
Available date2024-04-30T05:47:45Z
Publication Date2013
Publication NameBMC Infectious Diseases
ResourceScopus
Identifierhttp://dx.doi.org/10.1186/1471-2334-13-560
ISSN14712334
URIhttp://hdl.handle.net/10576/54476
AbstractBackground: Invasive fungal infections (IFI) are associated with considerable expense and mortality on healthcare systems. There is a need to provide evidence of both clinical efficacy and value for money with any health technology. The current pharmacoeconomic evaluation investigated the use of liposomal amphotericin B (LAmB) and voriconazole for the empiric treatment of IFI in the Turkish setting.Methods: Decision analytic modelling was used to create a pathway for patient treatment with a 5-point composite outcome measure. The data was obtained from a major non-inferiority multicentre randomised controlled study, with an expert panel of clinicians in Turkey providing transition probabilities and cost not available in the literature. Sensitivity analyses were performed on the inputs from the clinical trial and the expert panel.Results: As per the base case analysis, voriconazole was preferred by Turkish Lira (TL) 2,523 per patient treated and TL2,520 per surviving patient. LAmB was the preferred alternative by TL5,362 per successfully treated patient. Removing fever resolution as part of the composite outcome measure resulted in voriconazole being the preferred alternative per successfully treated patient. Univariate sensitivity analysis highlighted that increasing the duration of voriconazole by >1.2 days or decreasing LAmB by >1.0 days changes the result. Monte Carlo Simulation resulted in 69.4% of simulations favouring voriconazole per patient treated.Conclusion: There is a strong likelihood that voriconazole is economically more favourable than LAmB in the empiric treatment of IFI in Turkey.
Languageen
PublisherBMC
SubjectAntifungal agents
Economic evaluation
Empiric therapy
Invasive fungal infection
Liposomal amphotericin B
Voriconazole
TitlePharmacoeconomic evaluation of voriconazole vs. liposomal amphotericin B in empiric treatment of invasive fungal infections in Turkey
TypeArticle
Issue Number1
Volume Number13
dc.accessType Open Access


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