عرض بسيط للتسجيلة

المؤلفDerbala, Moutaz
المؤلفRizk, Nasser
المؤلفShebl, Fatima
المؤلفAlkaabi, Saad
المؤلفEldweik, Nazeeh
المؤلفJohn, Anil
المؤلفSharma, Manik
المؤلفYaqoob, Rafe
المؤلفAlmohanadi, Muneera
المؤلفButt, Mohammed
المؤلفAlejji, Khaled
تاريخ الإتاحة2024-05-23T07:11:46Z
تاريخ النشر2012-12-21
اسم المنشورWorld Journal of Gastroenterology
المعرّفhttp://dx.doi.org/10.3748/wjg.v18.i47.7003
الاقتباسDerbala, M., Rizk, N., Shebl, F., Alkaabi, S., Eldweik, N., John, A., ... & Alejji, K. (2012). Interleukin-28 and hepatitis C virus genotype-4: treatment-induced clearance and liver fibrosis. World Journal of Gastroenterology: WJG, 18(47), 7003.
الرقم المعياري الدولي للكتاب1007-9327
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84873895893&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/55335
الملخصAIM: To investigate the association between interleukin-28B (IL28B) genotype and response to treatment and hepatic fibrosis in patients with hepatitis C virus (HCV) genotype 4. METHODS: Two hundred and one HCV-genotype 4 patients were included. All patients were treated with Peginterferon alph2a/Ribavirin for 48 wk. End of treatment response (ETR) was defined as loss of detectable serum HCV RNA at the end of treatment. Sustained viral response (SVR) was defined as loss of detectable serum HCV RNA at the end of 24 wk follow up. Genotyping of IL28B rs12979860 was performed using the TaqMan assay. We used logistic regression to estimate the adjusted odds ratio (aOR) and 95%CI. RESULTS: The study included 201 HCV-genotype 4 patients. The majority of patients were men (89.6%), with a median age of 47 years, inter-quartile range (40-51). Approximately 62.5% of patients had ETR, and 49.6% had SVR. Individuals who achieved SVR were more likely to be younger (χ2 = 4.91, P = 0.027), and less likely to have fibrosis (χ2 = 15.54, P < 0.0001), or inflammation (χ2 = 7.58, P = 0.006). The genotype distribution of rs12979860 was 36.2%, 49.0% and 14.8% for genotypes CC, CT, and TT, respectively. In these participants, rs12979860 genotype distribution did not differ by gender (P = 0.466), pretreatment viral load (P = 0.600), inflammation (P = 0.435), or fibrosis (P = 0.291). The frequencies of IL28B rs12979860 genotypes were TT (14.8%), CT (49.0%), and CC (36.2%). Compared to rs12979860 genotype TT, aORs (95%CI) for ETR and SVR were: CC genotype, [17.55 (5.34-57.69) and 5.92 (2.09-16.76), respectively]; CT genotype, [5.15 (1.80-14.78) and 2.48 (0.94-6.52), respectively]. In the current study, the patients who did not achieve ETR or SVR had a lower prevalence of rs12979860 CC (17.4% and 23.3%, respectively) than individuals who had ETR or SVR (47.9% and 47.2%, respectively). Individuals with rs12979860 CC genotype had approximately 6 times the odds of SVR compared to individuals with TT genotype (aOR = 5.92; 95%CI: 2.09-16.76). Similarly, patients with CT genotype had SVR more often than patients with TT genotype (aOR = 2.48; 95%CI: 0.94-6.52). Carrying at least one copy of the C allele (genotypes CT and CC) had almost 8 times the probability of ETR compared to those with genotype rs12979860 TT (aOR = 7.87; 95%CI: 2.84-21.82), and approximately 3 times the odds of SVR compared to those with genotype rs12979860 TT (aOR = 3.46; 95%CI: 1.37-8.74). In addition, data were consistent with a signifcant gene-dose relationship (aOR = 4.05/allele; 95%CI: 2.27-7.22). The association between rs12979860 genotype and SVR was similar among those who achieved and those who did not achieve SVR. CONCLUSION: In HCV-genotype 4 patients, rs12979860 is a sensitive predictor of viral clearance, independent of viral load, age, gender or fibrosis, with no similar relation to severity of fibrosis. © 2012 Baishideng. All rights reserved.
اللغةen
الناشرBaishideng Publishing Group
الموضوعGenotype 4
Hepatic fibrosis
Hepatitis C virus
Interleukin-28B
rs12979860
العنوانInterleukin-28 and hepatitis C virus genotype-4: Treatmentinduced clearance and liver fibrosis
النوعArticle
الصفحات7003-7008
رقم العدد47
رقم المجلد18
ESSN2219-2840
dc.accessType Open Access


الملفات في هذه التسجيلة

Thumbnail

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة