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المؤلفEsh, Christopher J.
المؤلفChrismas, Bryna C.R.
المؤلفMauger, Alexis R.
المؤلفCherif, Anissa
المؤلفMolphy, John
المؤلفTaylor, Lee
تاريخ الإتاحة2024-05-29T10:46:19Z
تاريخ النشر2021-03-22
اسم المنشورScientific Reports
المعرّفhttp://dx.doi.org/10.1038/s41598-021-84563-5
الاقتباسEsh, C. J., Chrismas, B. C., Mauger, A. R., Cherif, A., Molphy, J., & Taylor, L. (2021). The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans. Scientific Reports, 11(1), 6531.
الرقم المعياري الدولي للكتاب2045-2322
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85103169297&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/55645
الملخصWhether cyclooxygenase (COX)/prostaglandin E2 (PGE2) thermoregulatory pathways, observed in rodents, present in humans? Participants (n = 9) were exposed to three environments; cold (20 °C), thermoneutral (30 °C) and hot (40 °C) for 120 min. Core (Tc)/skin temperature and thermal perception were recorded every 15 min, with COX/PGE2 concentrations determined at baseline, 60 and 120 min. Linear mixed models identified differences between and within subjects/conditions. Random coefficient models determined relationships between Tc and COX/PGE2. Tc [mean (range)] increased in hot [+ 0.8 (0.4–1.2) °C; p < 0.0001; effect size (ES): 2.9], decreased in cold [− 0.5 (− 0.8 to − 0.2) °C; p < 0.0001; ES 2.6] and was unchanged in thermoneutral [+ 0.1 (− 0.2 to 0.4) °C; p = 0.3502]. A relationship between COX2/PGE2 in cold (p = 0.0012) and cold/thermoneutral [collapsed, condition and time (p = 0.0243)] was seen, with higher PGE2 associated with higher Tc. A within condition relationship between Tc/PGE2 was observed in thermoneutral (p = 0.0202) and cold/thermoneutral [collapsed, condition and time (p = 0.0079)] but not cold (p = 0.0631). The data suggests a thermogenic response of the COX/PGE2 pathway insufficient to defend Tc in cold. Further human in vivo research which manipulates COX/PGE2 bioavailability and participant acclimation/acclimatization are warranted to elucidate the influence of COX/PGE2 on Tc.
راعي المشروعThis work was funded by Aspire Zone Foundation (Doha, Qatar).
اللغةen
الناشرSpringer Nature
الموضوعbody temperature
sport
العنوانThe influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans
النوعArticle
رقم العدد1
رقم المجلد11
dc.accessType Open Access


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