Association between antioxidant metabolites and N-terminal fragment brain natriuretic peptides in insulin-resistant individuals.
المؤلف | Anwardeen, Najeha |
المؤلف | Naja, Khaled |
المؤلف | Elrayess, Mohamed A |
تاريخ الإتاحة | 2024-06-03T05:01:58Z |
تاريخ النشر | 2024 |
اسم المنشور | Cardiovascular Endocrinology & Metabolism |
المعرّف | http://dx.doi.org/10.1097/XCE.0000000000000303 |
الاقتباس | Anwardeen, Najehaa,*; Naja, Khaleda,*; Elrayess, Mohamed A.a,b. Association between antioxidant metabolites and N-terminal fragment brain natriuretic peptides in insulin-resistant individuals. Cardiovascular Endocrinology & Metabolism 13(2):e0303, June 2024. | DOI: 10.1097/XCE.0000000000000303 |
الرقم المعياري الدولي للكتاب | 2574-0954 |
الملخص | Oxidative stress plays a pivotal role in the development of metabolic syndrome, including heart failure and insulin resistance. The N-terminal fragment of brain natriuretic peptide (NT-proBNP) has been associated with heightened oxidative stress in heart failure patients. Yet, its correlation with insulin resistance remains poorly understood. Our objective is to investigate the association between oxidative stress markers and NT-proBNP levels in insulin-resistant individuals. In this cross-sectional study involving 393 participants from the Qatar Biobank, clinical and metabolic data were collected, and the association between NT-proBNP and 72 oxidative stress metabolites was compared between insulin-sensitive and insulin-resistant individuals. Our results showed significantly lower NT-proBNP levels in insulin-resistant individuals (median = 17 pg/ml; interquartile range = 10.3-29) when compared to their insulin-sensitive counterparts (median = 31 pg/ml; interquartile range = 19-57). Moreover, we revealed notable associations between NT-proBNP levels and antioxidant metabolic pathways, particularly those related to glutathione metabolism, in insulin-resistant, but not insulin-sensitive individuals. The significant decrease in NT-proBNP observed in individuals with insulin resistance may be attributed to a direct or indirect enhancement in glutathione production, which is regarded as a compensatory mechanism against oxidative stress. This study could advance our understanding of the interplay between oxidative stress during insulin resistance and cardiovascular risk, which could lead to novel therapeutic approaches for managing cardiovascular diseases. Further investigations are needed to assess the practical utility of these potential metabolites and understand the causal nature of their association with NT-proBNP in the etiology of insulin resistance. |
راعي المشروع | The authors would like to acknowledge Qatar Biobank for providing the data. This research was funded by Qatar National Research Fund (QNRF), grant number NPRP13S-1230-190008. K.N. wrote the article, N.A. wrote the article and supported the statistical analysis, and M.A.E. supervised the work. All authors have read and agreed to the published version of the manuscript. The study was approved by the Institutional Review Boards of the Qatar Biobank (QF-QBB-RES-ACC-00125). Informed consent was obtained from all participants involved in the study. The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. |
اللغة | en |
الناشر | Lippincott, Williams & Wilkins |
الموضوع | NT-proBNP antioxidant insulin resistance metabolomics |
النوع | Article |
رقم العدد | 2 |
رقم المجلد | 13 |
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