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المؤلفMukhtar, Imran
المؤلفAnwar, Haseeb
المؤلفMirza, Osman Asghar
المؤلفAli, Qasim
المؤلفIjaz, Muhammad Umar
المؤلفHume, Michael
المؤلفPrabhala, Bala Krishna
المؤلفIftikhar, Arslan
المؤلفHussain, Ghulam
المؤلفSohail, Muhammad Umar
المؤلفKhan, Kashif ur Rehman
تاريخ الإتاحة2024-06-03T11:29:12Z
تاريخ النشر2021
اسم المنشورDose-Response
المعرّفhttp://dx.doi.org/10.1177/1559325820987943
الاقتباسMukhtar, I., Anwar, H., Mirza, O. A., Ali, Q., Ijaz, M. U., Hume, M., ... & Khan, K. U. R. (2021). Sulpiride serves, a substrate for the gut microbiome. Dose-Response, 19(1), 1559325820987943.
الرقم المعياري الدولي للكتاب1559-3258
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85100956617&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/55788
الملخصIn the contemporary research world, the intestinal microbiome is now envisioned as a new body organ. Recently, the gut microbiome represents a new drug target in the gut, since various orthologues of intestinal drug transporters are also found present in the microbiome that lines the small intestine of the host. Owing to this, absorbance of sulpiride by the gut microbiome in an in vivo albino rats model was assessed after the oral administration with a single dose of 20mg/kg b.w. The rats were subsequently sacrificed at 2, 3, 4, 5 and 6 hours post oral administration to collect the gut microbial mass pellet. The drug absorbance by the gut microbiome was determined by pursuing the microbial lysate through RP-HPLC-UV. Total absorbance of sulpiride by the whole gut microbiome and drug absorbance per milligram of microbial pellet were found significantly higher at 4 hours post-administration as compared to all other groups. These results affirm the hypothesis that the structural homology between membrane transporters of the gut microbiome and intestinal epithelium of the host might play an important role in drug absorbance by gut microbes in an in vivo condition.
راعي المشروعThis work was supported by the Department of Physiology, Government College University Faisalabad, Pakistan.
اللغةen
الناشرInternational Dose-Response Society
الموضوعgut microbiome
microbial lysate
microbial mass pellet
sulpiride
العنوانSulpiride Serves, a Substrate for the Gut Microbiome
النوعArticle
رقم العدد1
رقم المجلد19
dc.accessType Open Access


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