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AuthorMukhtar, Imran
AuthorAnwar, Haseeb
AuthorMirza, Osman Asghar
AuthorAli, Qasim
AuthorIjaz, Muhammad Umar
AuthorHume, Michael
AuthorPrabhala, Bala Krishna
AuthorIftikhar, Arslan
AuthorHussain, Ghulam
AuthorSohail, Muhammad Umar
AuthorKhan, Kashif ur Rehman
Available date2024-06-03T11:29:12Z
Publication Date2021
Publication NameDose-Response
Identifierhttp://dx.doi.org/10.1177/1559325820987943
CitationMukhtar, I., Anwar, H., Mirza, O. A., Ali, Q., Ijaz, M. U., Hume, M., ... & Khan, K. U. R. (2021). Sulpiride serves, a substrate for the gut microbiome. Dose-Response, 19(1), 1559325820987943.
ISSN1559-3258
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85100956617&origin=inward
URIhttp://hdl.handle.net/10576/55788
AbstractIn the contemporary research world, the intestinal microbiome is now envisioned as a new body organ. Recently, the gut microbiome represents a new drug target in the gut, since various orthologues of intestinal drug transporters are also found present in the microbiome that lines the small intestine of the host. Owing to this, absorbance of sulpiride by the gut microbiome in an in vivo albino rats model was assessed after the oral administration with a single dose of 20mg/kg b.w. The rats were subsequently sacrificed at 2, 3, 4, 5 and 6 hours post oral administration to collect the gut microbial mass pellet. The drug absorbance by the gut microbiome was determined by pursuing the microbial lysate through RP-HPLC-UV. Total absorbance of sulpiride by the whole gut microbiome and drug absorbance per milligram of microbial pellet were found significantly higher at 4 hours post-administration as compared to all other groups. These results affirm the hypothesis that the structural homology between membrane transporters of the gut microbiome and intestinal epithelium of the host might play an important role in drug absorbance by gut microbes in an in vivo condition.
SponsorThis work was supported by the Department of Physiology, Government College University Faisalabad, Pakistan.
Languageen
PublisherInternational Dose-Response Society
Subjectgut microbiome
microbial lysate
microbial mass pellet
sulpiride
TitleSulpiride Serves, a Substrate for the Gut Microbiome
TypeArticle
Issue Number1
Volume Number19
dc.accessType Open Access


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