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المؤلفRupel, Katia
المؤلفZupin, Luisa
المؤلفBrich, Silvia
المؤلفMardirossian, Mario
المؤلفOttaviani, Giulia
المؤلفGobbo, Margherita
المؤلفDi Lenarda, Roberto
المؤلفPricl, Sabrina
المؤلفCrovella, Sergio
المؤلفZacchigna, Serena
المؤلفBiasotto, Matteo
تاريخ الإتاحة2024-07-21T06:24:22Z
تاريخ النشر2021
اسم المنشورJournal of Biophotonics
المصدرScopus
المعرّفhttp://dx.doi.org/10.1002/jbio.202000350
الرقم المعياري الدولي للكتاب1864063X
معرّف المصادر الموحدhttp://hdl.handle.net/10576/56862
الملخصThe aim of this work was to assess the antimicrobial efficacy on Pseudomonas aeruginosa of nanomicelles loaded with curcumin (CUR) alone and activated by blue laser light in an antimicrobial photodynamic therapy (APDT) approach. First, free CUR in liquid suspension and loaded in three amphiphilic nanomicelles (CUR-DAPMA, CUR-SPD and CUR-SPM) were tested both on bacteria and keratinocytes. While free CUR exerted limited efficacy showing moderate cytotoxicity, a strong inhibition of bacterial growth was obtained using all three nanosystems without toxicity on eukaryotic cells. CUR-SPM emerged as the most effective, and was therefore employed in APDT experiments. Among the three sublethal blue laser (λ 445 nm) protocols tested, the ones characterized by a fluence of 18 and 30 J/cm2 further decreased the antimicrobial concentration to 50 nM. The combination of blue laser APDT with CUR-SPM nanomicelles results in an effective synergistic activity that represents a promising novel therapeutic approach on resistant species.
اللغةen
الناشرwiley
الموضوعantimicrobial
blue laser
curcumin
nanomicelles
photodynamic therapy
العنوانAntimicrobial activity of amphiphilic nanomicelles loaded with curcumin against Pseudomonas aeruginosa alone and activated by blue laser light
النوعArticle
رقم العدد3
رقم المجلد14
dc.accessType Abstract Only


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