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المؤلفJoyce, M. Gordon
المؤلفWheatley, Adam K.
المؤلفThomas, Paul V.
المؤلفChuang, Gwo-Yu
المؤلفSoto, Cinque
المؤلفBailer, Robert T.
المؤلفDruz, Aliaksandr
المؤلفGeorgiev, Ivelin S.
المؤلفGillespie, Rebecca A.
المؤلفKanekiyo, Masaru
المؤلفKong, Wing-Pui
المؤلفLeung, Kwanyee
المؤلفNarpala, Sandeep N.
المؤلفPrabhakaran, Madhu S.
المؤلفYang, Eun Sung
المؤلفZhang, Baoshan
المؤلفZhang, Yi
المؤلفAsokan, Mangaiarkarasi
المؤلفBoyington, Jeffrey C.
المؤلفBylund, Tatsiana
المؤلفDarko, Sam
المؤلفLees, Christopher R.
المؤلفRansier, Amy
المؤلفShen, Chen-Hsiang
المؤلفWang, Lingshu
المؤلفWhittle, James R.
المؤلفWu, Xueling
المؤلفYassine, Hadi M.
المؤلفSantos, Celia
المؤلفMatsuoka, Yumiko
المؤلفTsybovsky, Yaroslav
المؤلفBaxa, Ulrich
المؤلفMullikin, James C.
المؤلفSubbarao, Kanta
المؤلفDouek, Daniel C.
المؤلفGraham, Barney S.
المؤلفKoup, Richard A.
المؤلفLedgerwood, Julie E.
المؤلفRoederer, Mario
المؤلفShapiro, Lawrence
المؤلفKwong, Peter D.
المؤلفMascola, John R.
المؤلفMcDermott, Adrian B.
تاريخ الإتاحة2017-11-05T10:10:45Z
تاريخ النشر2016-07-28
اسم المنشورCell
المعرّفhttp://dx.doi.org/10.1016/j.cell.2016.06.043
الاقتباسM. Gordon Joyce, Adam K. Wheatley, Paul V. Thomas, Gwo-Yu Chuang, Cinque Soto, Robert T. Bailer, Aliaksandr Druz, Ivelin S. Georgiev, Rebecca A. Gillespie, Masaru Kanekiyo, Wing-Pui Kong, Kwanyee Leung, Sandeep N. Narpala, Madhu S. Prabhakaran, Eun Sung Yang, Baoshan Zhang, Yi Zhang, Mangaiarkarasi Asokan, Jeffrey C. Boyington, Tatsiana Bylund, Sam Darko, Christopher R. Lees, Amy Ransier, Chen-Hsiang Shen, Lingshu Wang, James R. Whittle, Xueling Wu, Hadi M. Yassine, Celia Santos, Yumiko Matsuoka, Yaroslav Tsybovsky, Ulrich Baxa, James C. Mullikin, Kanta Subbarao, Daniel C. Douek, Barney S. Graham, Richard A. Koup, Julie E. Ledgerwood, Mario Roederer, Lawrence Shapiro, Peter D. Kwong, John R. Mascola, Adrian B. McDermott, Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses, In Cell, Volume 166, Issue 3, 2016, Pages 609-623, ISSN 0092-8674, https://doi.org/10.1016/j.cell.2016.06.043.
الرقم المعياري الدولي للكتاب0092-8674
المعرّفPMCID: PMC4978566
معرّف المصادر الموحدhttp://www.sciencedirect.com/science/article/pii/S0092867416308510
معرّف المصادر الموحدhttp://hdl.handle.net/10576/5730
الملخصAntibodies capable of neutralizing divergent influenza A viruses could form the basis of a universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza vaccine trial, we sorted hemagglutinin cross-reactive memory B cells and identified three antibody classes, each capable of neutralizing diverse subtypes of group 1 and group 2 influenza A viruses. Co-crystal structures with hemagglutinin revealed that each class utilized characteristic germline genes and convergent sequence motifs to recognize overlapping epitopes in the hemagglutinin stem. All six analyzed subjects had sequences from at least one multidonor class, and—in half the subjects—multidonor-class sequences were recovered from >40% of cross-reactive B cells. By contrast, these multidonor-class sequences were rare in published antibody datasets. Vaccination with a divergent hemagglutinin can thus increase the frequency of B cells encoding broad influenza A-neutralizing antibodies. We propose the sequence signature-quantified prevalence of these B cells as a metric to guide universal influenza A immunization strategies.
اللغةen
الناشرElsevier Inc.
الموضوعVaccine
Influenza
العنوانVaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses
النوعArticle
الصفحات609-623
رقم العدد3
رقم المجلد166
Open Access user License http://www.elsevier.com/open-access/userlicense/1.0/
ESSN1097-4172
dc.accessType Abstract Only


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