Show simple item record

AuthorJoyce, M. Gordon
AuthorWheatley, Adam K.
AuthorThomas, Paul V.
AuthorChuang, Gwo-Yu
AuthorSoto, Cinque
AuthorBailer, Robert T.
AuthorDruz, Aliaksandr
AuthorGeorgiev, Ivelin S.
AuthorGillespie, Rebecca A.
AuthorKanekiyo, Masaru
AuthorKong, Wing-Pui
AuthorLeung, Kwanyee
AuthorNarpala, Sandeep N.
AuthorPrabhakaran, Madhu S.
AuthorYang, Eun Sung
AuthorZhang, Baoshan
AuthorZhang, Yi
AuthorAsokan, Mangaiarkarasi
AuthorBoyington, Jeffrey C.
AuthorBylund, Tatsiana
AuthorDarko, Sam
AuthorLees, Christopher R.
AuthorRansier, Amy
AuthorShen, Chen-Hsiang
AuthorWang, Lingshu
AuthorWhittle, James R.
AuthorWu, Xueling
AuthorYassine, Hadi M.
AuthorSantos, Celia
AuthorMatsuoka, Yumiko
AuthorTsybovsky, Yaroslav
AuthorBaxa, Ulrich
AuthorMullikin, James C.
AuthorSubbarao, Kanta
AuthorDouek, Daniel C.
AuthorGraham, Barney S.
AuthorKoup, Richard A.
AuthorLedgerwood, Julie E.
AuthorRoederer, Mario
AuthorShapiro, Lawrence
AuthorKwong, Peter D.
AuthorMascola, John R.
AuthorMcDermott, Adrian B.
Available date2017-11-05T10:10:45Z
Publication Date2016-07-28
Publication NameCell
Identifierhttp://dx.doi.org/10.1016/j.cell.2016.06.043
CitationM. Gordon Joyce, Adam K. Wheatley, Paul V. Thomas, Gwo-Yu Chuang, Cinque Soto, Robert T. Bailer, Aliaksandr Druz, Ivelin S. Georgiev, Rebecca A. Gillespie, Masaru Kanekiyo, Wing-Pui Kong, Kwanyee Leung, Sandeep N. Narpala, Madhu S. Prabhakaran, Eun Sung Yang, Baoshan Zhang, Yi Zhang, Mangaiarkarasi Asokan, Jeffrey C. Boyington, Tatsiana Bylund, Sam Darko, Christopher R. Lees, Amy Ransier, Chen-Hsiang Shen, Lingshu Wang, James R. Whittle, Xueling Wu, Hadi M. Yassine, Celia Santos, Yumiko Matsuoka, Yaroslav Tsybovsky, Ulrich Baxa, James C. Mullikin, Kanta Subbarao, Daniel C. Douek, Barney S. Graham, Richard A. Koup, Julie E. Ledgerwood, Mario Roederer, Lawrence Shapiro, Peter D. Kwong, John R. Mascola, Adrian B. McDermott, Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses, In Cell, Volume 166, Issue 3, 2016, Pages 609-623, ISSN 0092-8674, https://doi.org/10.1016/j.cell.2016.06.043.
ISSN0092-8674
IdentifierPMCID: PMC4978566
URIhttp://www.sciencedirect.com/science/article/pii/S0092867416308510
URIhttp://hdl.handle.net/10576/5730
AbstractAntibodies capable of neutralizing divergent influenza A viruses could form the basis of a universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza vaccine trial, we sorted hemagglutinin cross-reactive memory B cells and identified three antibody classes, each capable of neutralizing diverse subtypes of group 1 and group 2 influenza A viruses. Co-crystal structures with hemagglutinin revealed that each class utilized characteristic germline genes and convergent sequence motifs to recognize overlapping epitopes in the hemagglutinin stem. All six analyzed subjects had sequences from at least one multidonor class, and—in half the subjects—multidonor-class sequences were recovered from >40% of cross-reactive B cells. By contrast, these multidonor-class sequences were rare in published antibody datasets. Vaccination with a divergent hemagglutinin can thus increase the frequency of B cells encoding broad influenza A-neutralizing antibodies. We propose the sequence signature-quantified prevalence of these B cells as a metric to guide universal influenza A immunization strategies.
Languageen
PublisherElsevier Inc.
SubjectVaccine
Influenza
TitleVaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses
TypeArticle
Pagination609-623
Issue Number3
Volume Number166
Open Access user License http://www.elsevier.com/open-access/userlicense/1.0/
ESSN1097-4172
dc.accessType Abstract Only


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record