Iron shuttle chelation therapy enhances to reduce misplaced iron on secondary iron overloaded adult zebrafish
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Date
2017-03-16Author
Mustafa, IbrahimKhalaf, Israa Magdi Nassef
Younes, Salma Nagy
Saleem, Rola
Nasrellah, Gheyath
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Show full item recordAbstract
Thalassemia is the most common genetically inherited blood disorder in the world arises from defect in hemoglobin
production, results in ineffective erythropoiesis and the rapid destruction of RBC in the periphery that leads to severe
anemia. While transfusion therapy corrects the anemia, it gives rise to secondary iron overload. The current available
iron chelation therapy has issues with toxicity and compliance. Our hypothesis is iron shuttle chelation therapy using
combined iron chelators may have better effect in iron loaded adult zebrafish.
DOI/handle
http://hdl.handle.net/10576/5752Collections
- Biomedical Sciences [724 items ]