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AuthorMabrey, Gina
AuthorKoozehchian, Majid S.
AuthorNewton, Andrew T.
AuthorNaderi, Alireza
AuthorForbes, Scott C.
AuthorHaddad, Monoem
Available date2024-08-11T05:39:16Z
Publication Date2024
Publication NameNutrients
ResourceScopus
ISSN20726643
URIhttp://dx.doi.org/10.3390/nu16060766
URIhttp://hdl.handle.net/10576/57532
AbstractThis study examined the effect of creatine nitrate and caffeine alone and combined on exercise performance and cognitive function in resistance-trained athletes. In a double-blind, randomized crossover trial, twelve resistance-trained male athletes were supplemented with 7 days of creatine nitrate (5 g/day), caffeine (400 mg/day), and a combination of creatine nitrate and caffeine. The study involved twelve resistance-trained male athletes who initially provided a blood sample for comprehensive safety analysis, including tests for key enzymes and a lipid profile, and then performed standardized resistance exercises-bench and leg press at 70% 1RM-and a Wingate anaerobic power test. Cognitive function and cardiovascular responses were also examined forty-five minutes after supplementation. Creatine nitrate and caffeine that were co-ingested significantly enhanced cognitive function, as indicated by improved scores in the Stroop Word-Color Interference test (p = 0.04; effect size = 0.163). Co-ingestion was more effective than caffeine alone in enhancing cognitive performance. In contrast, no significant enhancements in exercise performance were observed. The co-ingestion of creatine nitrate and caffeine improved cognitive function, particularly in cognitive interference tasks, without altering short-term exercise performance. Furthermore, no adverse events were reported. Overall, the co-ingestion of creatine nitrate and caffeine appears to enhance cognition without any reported side effects for up to seven days.
SponsorThis research was funded by Jacksonville State University, grant number 10000-30217-70000-20.
Languageen
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
Subjectcaffeine
cognitive function
creatine nitrate
dietary supplements
ergogenic aids
exercise performance
resistance training
sports nutrition
TitleThe Effect of Creatine Nitrate and Caffeine Individually or Combined on Exercise Performance and Cognitive Function: A Randomized, Crossover, Double-Blind, Placebo-Controlled Trial
TypeArticle
Issue Number6
Volume Number16
dc.accessType Open Access


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