The Effect of Creatine Nitrate and Caffeine Individually or Combined on Exercise Performance and Cognitive Function: A Randomized, Crossover, Double-Blind, Placebo-Controlled Trial
Author | Mabrey, Gina |
Author | Koozehchian, Majid S. |
Author | Newton, Andrew T. |
Author | Naderi, Alireza |
Author | Forbes, Scott C. |
Author | Haddad, Monoem |
Available date | 2024-08-11T05:39:16Z |
Publication Date | 2024 |
Publication Name | Nutrients |
Resource | Scopus |
ISSN | 20726643 |
Abstract | This study examined the effect of creatine nitrate and caffeine alone and combined on exercise performance and cognitive function in resistance-trained athletes. In a double-blind, randomized crossover trial, twelve resistance-trained male athletes were supplemented with 7 days of creatine nitrate (5 g/day), caffeine (400 mg/day), and a combination of creatine nitrate and caffeine. The study involved twelve resistance-trained male athletes who initially provided a blood sample for comprehensive safety analysis, including tests for key enzymes and a lipid profile, and then performed standardized resistance exercises-bench and leg press at 70% 1RM-and a Wingate anaerobic power test. Cognitive function and cardiovascular responses were also examined forty-five minutes after supplementation. Creatine nitrate and caffeine that were co-ingested significantly enhanced cognitive function, as indicated by improved scores in the Stroop Word-Color Interference test (p = 0.04; effect size = 0.163). Co-ingestion was more effective than caffeine alone in enhancing cognitive performance. In contrast, no significant enhancements in exercise performance were observed. The co-ingestion of creatine nitrate and caffeine improved cognitive function, particularly in cognitive interference tasks, without altering short-term exercise performance. Furthermore, no adverse events were reported. Overall, the co-ingestion of creatine nitrate and caffeine appears to enhance cognition without any reported side effects for up to seven days. |
Sponsor | This research was funded by Jacksonville State University, grant number 10000-30217-70000-20. |
Language | en |
Publisher | Multidisciplinary Digital Publishing Institute (MDPI) |
Subject | caffeine cognitive function creatine nitrate dietary supplements ergogenic aids exercise performance resistance training sports nutrition |
Type | Article |
Issue Number | 6 |
Volume Number | 16 |
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