Whole genome sequencing in the Middle Eastern Qatari population identifies genetic associations with 45 clinically relevant traits
View/ Open
Date
2021-02-23Author
Thareja, GauravAl-Sarraj, Yasser
Belkadi, Aziz
Almotawa, Maryam
Ismail, Said
Al-Muftah, Wadha
Badji, Radja
Mbarek, Hamdi
Darwish, Dima
Fadl, Tasnim
Yasin, Heba
Ennaifar, Maryem
Abdellatif, Rania
Alkuwari, Fatima
Alvi, Muhammad
Saad, Chadi
Althani, Asmaa
Fethnou, Eleni
Qafoud, Fatima
Alkhayat, Eiman
Afifi, Nahla
Tomei, Sara
Liu, Wei
Lorenz, Stephan
Syed, Najeeb
Almabrazi, Hakeem
Vempalli, Fazulur Rehaman
Temanni, Ramzi
Saqri, Tariq Abu
Khatib, Mohammedhusen
Hamza, Mehshad
Zaid, Tariq Abu
El Khouly, Ahmed
Pathare, Tushar
Poolat, Shafeeq
Al-Ali, Rashid
Albagha, Omar M.E.
Al-Khodor, Souhaila
Alshafai, Mashael
Badii, Ramin
Chouchane, Lotfi
Estivill, Xavier
Fakhro, Khalid
Mokrab, Younes
Puthen, Jithesh
Tatari, Zohreh
Suhre, Karsten
...show more authors ...show less authors
Metadata
Show full item recordAbstract
Clinical laboratory tests play a pivotal role in medical decision making, but little is known about their genetic variability between populations. We report a genome-wide association study with 45 clinically relevant traits from the population of Qatar using a whole genome sequencing approach in a discovery set of 6218 individuals and replication in 7768 subjects. Trait heritability is more similar between Qatari and European populations (r = 0.81) than with Africans (r = 0.44). We identify 281 distinct variant-trait-associations at genome wide significance that replicate known associations. Allele frequencies for replicated loci show higher correlations with European (r = 0.94) than with African (r = 0.85) or Japanese (r = 0.80) populations. We find differences in linkage disequilibrium patterns and in effect sizes of the replicated loci compared to previous reports. We also report 17 novel and Qatari-predominate signals providing insights into the biological pathways regulating these traits. We observe that European-derived polygenic scores (PGS) have reduced predictive performance in the Qatari population which could have implications for the translation of PGS between populations and their future application in precision medicine.
Collections
- QU Health Research [71 items ]