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AuthorAlomari, Dalia Z.
AuthorSchierenbeck, Matías
AuthorAlqudah, Ahmad M.
AuthorAlqahtani, Mashael Daghash
AuthorWagner, Steffen
AuthorRolletschek, Hardy
AuthorBorisjuk, Ljudmilla
AuthorRöder, Marion S.
Available date2024-09-17T09:24:33Z
Publication Date2023-10-17
Publication NameNutrients
Identifierhttp://dx.doi.org/10.3390/nu15204398
CitationAlomari, D. Z., Schierenbeck, M., Alqudah, A. M., Alqahtani, M. D., Wagner, S., Rolletschek, H., ... & Röder, M. S. (2023). Wheat grains as a sustainable source of protein for health. Nutrients, 15(20), 4398.
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85175277023&origin=inward
URIhttp://hdl.handle.net/10576/59010
AbstractProtein deficiency is recognized among the major global health issues with an underestimation of its importance. Genetic biofortification is a cost-effective and sustainable strategy to overcome global protein malnutrition. This study was designed to focus on protein-dense grains of wheat (Triticum aestivum L.) and identify the genes governing grain protein content (GPC) that improve end-use quality and in turn human health. Genome-wide association was applied using the 90k iSELECT Infinium and 35k Affymetrix arrays with GPC quantified by using a proteomic-based technique in 369 wheat genotypes over three field-year trials. The results showed significant natural variation among bread wheat genotypes that led to detecting 54 significant quantitative trait nucleotides (QTNs) surpassing the false discovery rate (FDR) threshold. These QTNs showed contrasting effects on GPC ranging from −0.50 to +0.54% that can be used for protein content improvement. Further bioinformatics analyses reported that these QTNs are genomically linked with 35 candidate genes showing high expression during grain development. The putative candidate genes have functions in the binding, remobilization, or transport of protein. For instance, the promising QTN AX-94727470 on chromosome 6B increases GPC by +0.47% and is physically located inside the gene TraesCS6B02G384500 annotated as Trehalose 6-phosphate phosphatase (T6P), which can be employed to improve grain protein quality. Our findings are valuable for the enhancement of protein content and end-use quality in one of the major daily food resources that ultimately improve human nutrition.
SponsorThis research was supported by: - IPK Gatersleben core funding. - The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, grant 491250510). - Alexander von Humboldt Foundation (Georg Forster Fellowship). - The Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2023R355).
Languageen
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
Subjectbaking quality
bread wheat
candidate genes
flour
genetic biofortification
grain quality
GWAS
TitleWheat Grains as a Sustainable Source of Protein for Health
TypeArticle
Issue Number20
Volume Number15
ESSN2072-6643
dc.accessType Open Access


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