Browsing Biomedical Research Center by Author "Zedan, Hadeel T."
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Antibody-dependent enhancement (ADE) of SARS-CoV-2 in patients exposed to MERS-CoV and SARS-CoV-2 antigens
Thomas, Swapna; Smatti, Maria K.; Alsulaiti, Haya; Zedan, Hadeel T.; Eid, Ali H.; Hssain, Ali A.; Abu Raddad, Laith J.; Gentilcore, Giusy; Ouhtit, Allal; Althani, Asmaa A.; Nasrallah, Gheyath K.; Grivel, Jean Charles; Yassine, Hadi M.... more authors ... less authors ( Wiley , 2024 , Article)This study evaluated the potential for antibody-dependent enhancement (ADE) in serum samples from patients exposed to Middle East respiratory syndrome coronavirus (MERS-CoV). Furthermore, we evaluated the effect of severe ... -
Assessment of Broadly Reactive Responses in Patients With MERS-CoV Infection and SARS-CoV-2 Vaccination
Zedan, Hadeel T.; Smatti, Maria K.; Thomas, Swapna; Nasrallah, Gheyath K.; Afifi, Nahla M.; Hssain, Ali Ait; Abu Raddad, Laith J.; Coyle, Peter V.; Grivel, Jean Charles; Almaslamani, Muna A.; Althani, Asmaa A.; Yassine, Hadi M.... more authors ... less authors ( American Medical Association , 2023 , Article)Importance: In the ongoing COVID-19 pandemic, there remain unanswered questions regarding the nature and importance of the humoral immune response against other coronaviruses. Although coinfection of the Middle East ... -
Comparative analysis of within-host diversity among vaccinated COVID-19 patients infected with different SARS-CoV-2 variants
Hebah A., Al-Khatib; Smatti, Maria K.; Ali, Fatma H.; Zedan, Hadeel T.; Thomas, Swapna; Ahmed, Muna N.; El-kahlout, Reham A.; Al Bader, Mashael A.; Elgakhlab, Dina; Coyle, Peter V.; Abu-Raddad, Laith J.; Al Thani, Asma A.; Yassine, Hadi M.... more authors ... less authors ( Elsevier , 2022 , Article)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly evolving RNA virus that mutates within hosts and exists as viral quasispecies. Here, we evaluated the within-host diversity among vaccinated and ... -
Detection of Antinuclear Antibodies Targeting Intracellular Signal Transduction, Metabolism, Apoptotic Processes and Cell Death in Critical COVID-19 Patients
Nasarallah, Gheyath K.; Fakhroo, Aisha D.; Khan, Taushif; Cyprian, Farhan S.; Al Ali, Fatima; Ata, Manar M.A.; Taleb, Sara; Zedan, Hadeel T.; Al-Sadeq, Duaa W.; Amanullah, Fathima H.; Hssain, Ali A.; Eid, Ali H.; Abu-Raddad, Laith J.; Al-Khal, Abdullatif; Al Thani, Asmaa A.; Marr, Nico; Yassine, Hadi M.... more authors ... less authors ( Universita Cattolica del Sacro Cuore , 2022 , Article)Background and Objectives: The heterogeneity of the coronavirus disease of 2019 (COVID-19) lies within its diverse symptoms and severity, ranging from mild to lethal. Acute respiratory distress syndrome (ARDS) is a leading ... -
Evaluation of commercially available fully automated and ELISA-based assays for detecting anti-SARS-CoV-2 neutralizing antibodies
Zedan, Hadeel T.; Yassine, Hadi M.; Al-Sadeq, Duaa W.; Liu, Na; Qotba, Hamda; Nicolai, Eleonora; Pieri, Massimo; Bernardini, Sergio; Abu-Raddad, Laith J.; Nasrallah, Gheyath K.... more authors ... less authors ( Nature Research , 2022 , Article)Rapid and accurate measurement of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)-specific neutralizing antibodies (nAbs) is paramount for monitoring immunity in infected and vaccinated subjects. The current ... -
In vivo testing of novel nitric oxide-releasing nanoparticles for alleviating heart failure using the zebrafish embryo model
Maram, Hasan; Zedan, Hadeel T.; Al-Fakhroo, Dana; Elsayed Ibrahim, Hend; Abiib, Sumaya Ibrahim; El-Sherbiny, Ibrahim M.; Yalcin, Huseyin C.... more authors ... less authors ( Elsevier , 2024 , Article)Heart failure (HF) is a multifactorial, heterogeneous systemic disease that is considered one of the leading causes of death and morbidity worldwide. It is well-known that endothelial dysfunction (ED) plays an important ... -
SARS-CoV-2 infection triggers more potent antibody-dependent cellular cytotoxicity (ADCC) responses than mRNA-, vector-, and inactivated virus-based COVID-19 vaccines
Zedan, Hadeel T.; Smatti, Maria K.; Al-Sadeq, Duaa W.; Al Khatib, Hebah A.; Nicolai, Eleonora; Pieri, Massimo; Bernardini, Sergio; Hssain, Ali Ait; Taleb, Sara; Qotba, Hamda; Issa, Khodr; Abu Raddad, Laith J.; Althani, Asmaa A.; Nasrallah, Gheyath K.; Yassine, Hadi M.... more authors ... less authors ( Wiley , 2024 , Article)Neutralizing antibodies (NAbs) are elicited after infection and vaccination and have been well studied. However, their antibody-dependent cellular cytotoxicity (ADCC) functionality is still poorly characterized. Here, we ... -
Validation of a Novel Fluorescent Lateral Flow Assay for Rapid Qualitative and Quantitative Assessment of Total Anti-SARS-CoV-2 S-RBD Binding Antibody Units (BAU) from Plasma or Fingerstick Whole-Blood of COVID-19 Vaccinees
Younes, Nadin; Al-Sadeq, Duaa W.; Shurrab, Farah M.; Zedan, Hadeel T.; Abou-Saleh, Haissam; Abo-Halawa, Bushra Y.; AlHamaydeh, Fatima M.; Elsharafi, Amira E.; Daas, Hanin I.; Thomas, Swapna; Aboalmaaly, Sahar; Al Farsi, Afra; Al-Buainain, Reeham; Ataelmannan, Samar; Paul, Jiji; Al Saadi, Amana Salih; Yassine, Hadi M.; Majdalawieh, Amin F.; Ismail, Ahmed; Abu-Raddad, Laith J.; Nasrallah, Gheyath K.... more authors ... less authors ( MDPI , 2022 , Article)Background: Limited commercial LFA assays are available to provide a reliable quantitative measurement of the total binding antibody units (BAU/mL) against the receptor-binding domain of the SARS-CoV-2 spike protein (S-RBD). ...