Browsing Biomedical Research Center by Author "Kanekiyo, Masaru"

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Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses.

Boyoglu-Barnum, Seyhan; Hutchinson, Geoffrey B; Boyington, Jeffrey C; Moin, Syed M; Gillespie, Rebecca A; Tsybovsky, Yaroslav; Stephens, Tyler; Vaile, John R; Lederhofer, Julia; Corbett, Kizzmekia S; Fisher, Brian E; Yassine, Hadi M; Andrews, Sarah F; Crank, Michelle C; McDermott, Adrian B; Mascola, John R; Graham, Barney S; Kanekiyo, Masaru... more authors ... less authors ( Nature Research , 2020 , Article)
The conserved hemagglutinin (HA) stem has been a focus of universal influenza vaccine efforts. Influenza A group 1 HA stem-nanoparticles have been demonstrated to confer heterosubtypic protection in animals; however, the ...
Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation

Villar, Rina F.; Patel, Jinal; Weaver, Grant C.; Kanekiyo, Masaru; Wheatley, Adam K.; Yassine, Hadi M.; Costello, Catherine E.; Chandler, Kevin B.; McTamney, Patrick M.; Nabel, Gary J.; McDermott, Adrian B.; Mascola, John R.; Carr, Steven A.; Lingwood, Daniel... more authors ... less authors ( Nature Publishing Group , 2016 , Article)
Activation of immune cells (but not B cells) with lectins is widely known. We used the structurally defined interaction between influenza hemagglutinin (HA) and its cell surface receptor sialic acid (SA) to identify a B ...