Browsing Biomedical Research Center by Author "Marei, Hany E."
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Advances in osteobiologic materials for bone substitutes.
Hasan, Anwarul; Byambaa, Batzaya; Morshed, Mahboob; Cheikh, Mohammad Ibrahim; Shakoor, Rana Abdul; Mustafy, Tanvir; Marei, Hany E... more authors ... less authors ( John Wiley and Sons , 2018 , Article Review)A significant challenge in the current orthopedics is the development of suitable osteobiologic materials that can replace the conventional allografts, autografts, and xenografts and thereby serve as implant materials as ... -
Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)
Sartelli, Massimo; Weber, Dieter; Ruppé, Etienne; Bassetti, Matteo; Wright, Brian; Althani, Asmaa; Marei, Hany E.... more authors ... less authors ( BioMed Central , 2016 , Article)Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely ... -
Aspirin inhibits cancer stem cells properties and growth of glioblastoma multiforme through Rb1 pathway modulation.
Pozzoli, Giacomo; Marei, Hany E; Althani, Asma; Boninsegna, Alma; Casalbore, Patrizia; Marlier, Lionel N J L; Lanzilli, Giulia; Zonfrillo, Manuela; Petrucci, Giovanna; Rocca, Bianca; Navarra, Pierluigi; Sgambato, Alessandro; Cenciarelli, Carlo... more authors ... less authors ( Wiley , 2019 , Article)Several clinical studies indicated that the daily use of aspirin or acetylsalicylic acid reduces the cancer risk via cyclooxygenases (Cox-1 and Cox-2) inhibition. In addition, aspirin-induced Cox-dependent and -independent ... -
Common and Rare Genetic Variants Associated With Alzheimer's Disease
Marei, Hany E.; Althani, Asmaa; Suhonen, Jaana; El Zowalaty, Mohamed E.; Albanna, Mohammad A.; Cenciarelli, Carlo; Wang, Tengfei; Caceci, Thomas... more authors ... less authors ( WILEY PERIODICALS, INC. , 2016 , Article)Alzheimer's disease (AD) is one of the most devastating disorders. Despite the continuing increase of its incidence among aging populations, no effective cure has been developed mainly due to difficulties in early diagnosis ... -
Differentiation of human olfactory bulb-derived neural stem cells toward oligodendrocyte.
Marei, Hany E; Shouman, Zeinab; Althani, Asma; Afifi, Nahla; A, Abd-Elmaksoud; Lashen, Samah; Hasan, Anwarul; Caceci, Thomas; Rizzi, Roberto; Cenciarelli, Carlo; Casalbore, Patrizia... more authors ... less authors ( Wiley , 2018 , Article)In the central nervous system (CNS), oligodendrocytes are the glial element in charge of myelin formation. Obtaining an overall presence of oligodendrocyte precursor cells/oligodendrocytes (OPCs/OLs) in culture from different ... -
The effect of triiodothyronine on maturation and differentiation of oligodendrocyte progenitor cells during remyelination following induced demyelination in male albino rat
El-Tahry, H.; Marei, Hany E.; Shams, A.; El-Shahat, M.; Abdelaziz, H.; Abd El-kader, M.... more authors ... less authors ( Elsevier, Ltd , 2016 , Article)Demyelination was induced by two weeks cuprizone treatment. Rats of +ve control and triiodothyronine (T3) then received three subcutaneous injections of either saline or T3 day after day and sacrificed at the end of the ... -
Genetically unmatched human iPSC and ESC exhibit equivalent gene expression and neuronal differentiation potential.
Marei, Hany E; Althani, A; Lashen, S; Cenciarelli, C; Hasan, Anwarul ( Nature Publishing Group , 2017 , Article)The potential uniformity between differentiation and therapeutic potential of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) remains debatable. We studied the gene expression profiles, ... -
Glioma extracellular vesicles for precision medicine: prognostic and theragnostic application
Marei, Hany E.; Althani, Asmaa; Afifi, Nahla; Hasan, Anwarul; Caceci, Thomas; Cifola, Ingrid; Caratelli, Sara; Sconocchia, Giuseppe; D’Agnano, Igea; Cenciarelli, Carlo... more authors ... less authors ( Springer , 2022 , Article Review)EV produced by tumour cells carry a diverse population of proteins, lipids, DNA, and RNA molecules throughout the body and appear to play an important role in the overall development of the disease state, according to ... -
Human microbiome and its association with health and diseases
Al-Thani, Asma; Marei, Hany E.; Hamdi, Wedad S.; Nasrallah, Gheyath K.; El Zowalaty, Mohamed E.; Al Khdor, Souhaila; Al-Asmakh, Maha; Abdel-Aziz, Hassan... more authors ... less authors ( Wiley , 2016 , Article)Human microbiota are distinct communities of microorganisms that resides at different body niches. Exploration of the human microbiome has become a reality due to the availability of powerful metagenomics and metatranscriptomic ... -
Human Olfactory Bulb Neural Stem Cells Expressing hNGF Restore Cognitive Deficit in Alzheimer's Disease Rat Model
Marei, Hany E.; Farag, Amany; Al-Thani, Asma; Afifi, Nahla; Abd-Elmaksoud, Ahmed; Lashen, Samah; Rezk, Shaymaa; Pallini, Roberto; Casalbore, Patrizia; Cenciarelli, Carlo... more authors ... less authors ( Wiley , 2015 , Article)In this study, we aim to demonstrate the fate of allogenic adult human olfactory bulb neural stem/progenitor cells (OBNSC/NPCs) transplanted into the rat hippocampus treated with ibotenic acid (IBO), a neurotoxicant ... -
Human olfactory bulb neural stem cells mitigate movement disorders in a rat model of Parkinson's disease.
Marei, Hany E S; Lashen, Samah; Farag, Amany; Althani, Asmaa; Afifi, Nahla; A, Abd-Elmaksoud; Rezk, Shaymaa; Pallini, Roberto; Casalbore, Patrizia; Cenciarelli, Carlo... more authors ... less authors ( Wiley , 2015 , Article)Parkinson's disease (PD) is a neurological disorder characterized by the loss of midbrain dopaminergic (DA) neurons. Neural stem cells (NSCs) are multipotent stem cells that are capable of differentiating into different ... -
Landscape of NAT2 polymorphisms among breast cancer.
Tengfei, Wang; Marei, Hany E. ( Elsevier Masson , 2016 , Article)PURPOSE: The prevalence of phenotypes of Arylamine N-acetyltransferase-2(NAT2) gene (i.e. fast, intermediate and slow acetylators) among ethnic groups, as well as the association studies regarding NAT2 polymorphisms and ... -
Pandemic COVID-19 caused by SARS-CoV-2: genetic structure, vaccination, and therapeutic approaches
Marei, Hany E.; Althani, Asmaa; Afifi, Nahla; Pozzoli, Giacomo; Caceci, Thomas; Angelini, Franco; Cenciarelli, Carlo... more authors ... less authors ( Springer , 2021 , Article Review)We give a summary of SARS-genetic CoV-2’s structure and evolution, as well as current attempts to develop efficient vaccine and treatment methods for SARS-CoV-2 infection, in this article. Most therapeutic strategies are ... -
PDGFRα depletion attenuates glioblastoma stem cells features by modulation of STAT3, RB1 and multiple oncogenic signals.
Cenciarelli, Carlo; Marei, Hany E.; Felsani, Armando; Casalbore, Patrizia; Sica, Gigliola; Puglisi, Maria Ausiliatrice; Cameron, Angus J.M.; Olivi, Alessandro; Mangiola, Annunziato... more authors ... less authors ( Impact Journals , 2016 , Article)Platelet derived growth factor receptors (PDGFRs) play an important role in tumor pathogenesis, and they are frequently overexpressed in glioblastoma (GBM). Earlier we have shown a higher protein expression of PDGFR isoforms ... -
Potential of Stem Cell-Based Therapy for Ischemic Stroke.
Marei, Hany E; Hasan, A; Rizzi, R; Althani, A; Afifi, N; Cenciarelli, C; Caceci, Thomas; Shuaib, Ashfaq... more authors ... less authors ( Frontiers Media , 2018 , Article Review)Ischemic stroke is one of the major health problems worldwide. The only FDA approved anti-thrombotic drug for acute ischemic stroke is the tissue plasminogen activator. Several studies have been devoted to assessing the ... -
Pseudomonas aeruginosa: arsenal of resistance mechanisms, decades of changing resistance profiles, and future antimicrobial therapies.
El Zowalaty, Mohamed E.; Al Thani, Asmaa A.; Webster, Thomas J.; El Zowalaty, Ahmed E.; Schweizer, Herbert P.; Nasrallah, Gheyath K.; Marei, Hany E.; Ashour, Hossam M.... more authors ... less authors ( Future Medicine , 2015 , Article)Antimicrobial resistance is one of the most serious public health issues facing humans since the discovery of antimicrobial agents. The frequent, prolonged, and uncontrolled use of antimicrobial agents are major factors ... -
Recent Perspective About the Amyloid Cascade Hypothesis and Stem Cell-Based Therapy in the Treatment of Alzheimer's Disease
Marei, Hany E.; Althani, Asmaa; Suhonen, Jaana; El Zowalaty, Mohamed E.; Albanna, Mohammad A.; Cenciarelli, Carlo; Wang, Tengfei; Caceci, Thomas... more authors ... less authors ( Bentham Science , 2016 , Book chapter)Alzheimer's disease (AD) is a complex neurodegenerative condition that is clinically characterized by impaired cognitive functions. The major morphologically observed lesion of AD encompasses the accumulation of extracellular ... -
Recent perspective on CAR and Fcγ-CR T cell immunotherapy for cancers: Preclinical evidence versus clinical outcomes.
Marei, Hany E; Althani, Asma; Caceci, Thomas; Arriga, Roberto; Sconocchia, Tommaso; Ottaviani, Alessio; Lanzilli, Giulia; Roselli, Mario; Caratelli, Sara; Cenciarelli, Carlo; Sconocchia, Giuseppe... more authors ... less authors ( Elsevier , 2019 , Article)The chimeric antigen receptor Tcell (CAR-T cell) immunotherapy currently represents a hot research trend and it is expected to revolutionize the field of cancer therapy. Promising outcomes have been achieved using CAR-T ... -
Role of the Gastrointestinal Tract Microbiome in the Pathophysiology of Diabetes Mellitus.
Sohail, Muhammad U; Althani, Asmaa; Anwar, Haseeb; Rizzi, Roberto; Marei, Hany E ( Hindawi Publishing Corporation , 2017 , Article)The incidence of diabetes mellitus is rapidly increasing throughout the world. Although the exact cause of the disease is not fully clear, perhaps, genetics, ethnic origin, obesity, age, and lifestyle are considered as few ... -
Xeno-free trans-differentiation of adipose tissue-derived mesenchymal stem cells into glial and neuronal cells.
Elgamal, Aya; Althani A, Asmaa; Abd-Elmaksoud, Ahmed; Kassab, Mohammed; Farag, Amany; Lashen, Samah; Gabr, Mahmoud M; Zakaria, Mahmoud M; Alissawi, Mohga M; Ismail, Hossam El-Din Ali; Abd El Galil, Ahmed; Caceci, Thomas; Cenciarelli C, Carlo; Marei, Hany E... more authors ... less authors ( e-Century Publishing , 2019 , Article)Mesenchymal stem cells (MSCs) are undifferentiated cells that have the ability of self-renewal and trans-differentiation into other cell types. They hold out hope for finding a cure for many diseases. Nevertheless, there ...