Browsing Biomedical Research Center by Author "Marei, Isra"
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Activation and Contraction of Human “Vascular” Smooth Muscle Cells Grown From Circulating Blood Progenitors
Ahmetaj-Shala, Blerina; Marei, Isra; Kawai, Ryota; Rothery, Stephen; Pericleous, Charis; Mohamed, Nura A.; Gashaw, Hime; Bokea, Kalliopi; Samuel, Jake; Vandenheste, Annabelle; Shala, Fisnik; Kirkby, Nicholas S.; Mitchell, Jane A.... more authors ... less authors ( Frontiers Media , 2021 , Article)Blood outgrowth smooth muscle cells (BO-SMCs) offer the means to study vascular cells without the requirement for surgery providing opportunities for drug discovery, tissue engineering, and personalized medicine. However, ... -
Internalization of metal-organic framework nanoparticles in human vascular cells: Implications for cardiovascular disease therapy
Al-Ansari, Dana E.; Mohamed, Nura A.; Marei, Isra; Zekri, Atef; Kameno, Yu; Davies, Robert P.; Lickiss, Paul D.; Rahman, Md Mizanur; Abou-Saleh, Haissam... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2020 , Article)Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Alteration of endothelial cells and the underlying vasculature plays a central role in the pathogenesis of various CVDs. The ... -
Recent Developments in Nanomaterials-Based Drug Delivery and Upgrading Treatment of Cardiovascular Diseases
Mohamed, Nura A.; Marei, Isra; Crovella, Sergio; Abou-Saleh, Haissam ( MDPI , 2022 , Article)Cardiovascular diseases (CVDs) are the leading causes of morbidity and mortality worldwide. However, despite the recent developments in the management of CVDs, the early and long outcomes vary considerably in patients, ... -
Studies on metal–organic framework (MOF) nanomedicine preparations of sildenafil for the future treatment of pulmonary arterial hypertension
Mohamed, Nura A.; Abou-Saleh, Haissam; Kameno, Yu; Marei, Isra; de Nucci, Gilberto; Ahmetaj-Shala, Blerina; Shala, Fisnik; Kirkby, Nicholas S.; Jennings, Lewis; Al-Ansari, Dana E.; Davies, Robert P.; Lickiss, Paul D.; Mitchell, Jane A.... more authors ... less authors ( nature , 2021 , Article)Pulmonary arterial hypertension (PAH) is an incurable disease, although symptoms are treated with a range of dilator drugs. Despite their clinical benefits, these drugs are limited by systemic side-effects. It is, therefore, ...